Since its initial discovery as the gene altered in Tuberous Sclerosis Complex (TSC), an
autosomal dominant disorder, the interest in TSC1 (Tuberous Sclerosis Complex 1) has …

The tuberous sclerosis complex (TSC1/TSC2/TBC1D7) primarily functions to inhibit the
mechanistic target of rapamycin complex 1 (mTORC1), a crucial regulator of cell growth …

Pancreatic acinar cell carcinoma (ACC) is an aggressive exocrine tumor with largely
unknown biology. Here, to identify potential targets for personalized treatment, we perform …

Acinar cell carcinoma (ACC) of the pancreas is a malignant tumor of the exocrine cell
lineage with a poor prognosis. Due to its rare incidence and technical difficulties, few …

Aims/hypothesis Glucagon-like peptide (GLP-1), an intestinal incretin produced in L cells
through proglucagon processing, is released in response to meal intake. The intracellular …

Abstract Roux-en-Y Gastric Bypass Surgery (RYGB) prevents the occurrence of pancreatic
cell acinar carcinoma (ACC) in male and female Ngn3-Tsc1−/− mice. Ngn3 directed Cre …

It has been indicated that the combination of pancreatic and duodenal homeobox 1 (Pdx1),
MAF bZIP transcription factor A (MafA) and neurogenin 3 (Ngn3) was able to reprogram …

Background Pancreatic acinar cell carcinoma (PACC) is a rare malignancy, accounting for<
1% of all pancreatic neoplasms. Very few retrospective studies are available to help guide …

BACKGROUND Children of Hispanic ancestry have a higher incidence of acute
lymphoblastic leukemia (ALL) compared with other ethnic groups, but to the authors' …

Pancreatic cancer is a devastating disease with a universally poor prognosis. In 2015, it is
estimated that there will be 48,960 new cases of pancreatic cancer and that 40,560 people …