More is different: Reconstituting complexity in microtubule regulation

EJ Lawrence, S Chatterjee, M Zanic - Journal of Biological Chemistry, 2023 - ASBMB
Microtubules are dynamic cytoskeletal filaments that undergo stochastic switching between
phases of polymerization and depolymerization—a behavior known as dynamic instability …

Direct induction of microtubule branching by microtubule nucleation factor SSNA1

N Basnet, H Nedozralova, AH Crevenna… - Nature cell …, 2018 - nature.com
Microtubules are central elements of the eukaryotic cytoskeleton that often function as part of
branched networks. Current models for branching include nucleation of new microtubules …

SSNA1 stabilizes dynamic microtubules and detects microtubule damage

E Lawrence, G Arpag, C Arnaiz, M Zanic - Biophysical Journal, 2022 - cell.com
Sjögren's Syndrome Nuclear Autoantigen 1 (SSNA1/NA14) is a microtubule-associated
protein with important functions in cilia, dividing cells and developing neurons. However, the …

Spastin-interacting protein NA14/SSNA1 functions in cytokinesis and axon development

U Goyal, B Renvoisé, J Chang, C Blackstone - PloS one, 2014 - journals.plos.org
Hereditary spastic paraplegias (HSPs) are a genetically diverse group of inherited
neurological disorders (SPG1-72) with the cardinal feature of prominent lower-extremity …

The C. elegans homolog of Sjögrens Syndrome Nuclear Antigen 1 is required for the structural integrity of the centriole and bipolar mitotic spindle assembly

JA Pfister, L Agostini, L Bournonville, P Sankaralingam… - bioRxiv, 2024 - biorxiv.org
Centrioles play central roles in ciliogenesis and mitotic spindle assembly. Once assembled,
centrioles exhibit long-term stability, a property essential for maintaining numerical control …

Emergence of structure through protein–protein interactions and pH changes in dually predicted coiled-coil and disordered regions of centrosomal proteins

MA Treviño, MF García-Mayoral, MÁ Jiménez… - … et Biophysica Acta (BBA …, 2014 - Elsevier
Human centrosomal proteins show a significant, 3.5 fold, bias to be both unstructured and
coiled-coils with respect to generic human proteins, based on results from state of the art …

Conformational characterization of the intrinsically disordered protein Chibby: Interplay between structural elements in target recognition

RC Killoran, MA Sowole, MA Halim… - Protein …, 2016 - Wiley Online Library
Abstract The protein Chibby (Cby) is an antagonist of the Wnt signaling pathway, where it
inhibits the binding between the transcriptional coactivator β‐catenin and the Tcf/Lef …