The importance and role of the estrogen receptor (ER) pathway has been well-documented
in both breast cancer (BC) development and progression. The treatment of choice in women …

Abstract Estrogen receptor-positive (ER+) breast cancer accounts for approximately 75% of
all breast cancers. Endocrine therapies, including selective ER modulators (SERMs) …

The estrogen receptor is a vital receptor for therapeutic targets in estrogen receptor-positive
breast cancer. The main strategy for the treatment of estrogen receptor-positive breast …

Breast cancer is the most frequent female malignant tumor, and the leading cause of cancer
death in women worldwide. The most common subtype of breast cancer is hormone receptor …

While conventional cancer treatments, such as surgery, radiotherapy and chemotherapy,
have been combined for decades in an effort to treat cancer patients, the emergence of …

Progression to hormone‐independent growth leading to endocrine therapy resistance
occurs in a high proportion of patients with estrogen receptor alpha (ERα) and progesterone …

Heart failure (HF) is a principal cause of morbidity and mortality worldwide, affecting an
estimated 38 million people. Although significant progress has been made with respect to …

Steroid receptor coactivator-1 (SRC-1) is a transcription coactivator playing a pivotal role in
mediating a wide range of signaling pathways by interacting with related transcription factors …

Rapidly emerging ground-breaking discoveries have provided near to complete resolution
of breast cancer signaling landscape and scientists have mapped the knowledge gaps …

Simple Summary Altered nuclear receptor signaling is well-established to contribute to a
range of hormone-dependent cancers and therefore they are therapeutic targets, for …