The general secretory (Sec) pathway comprises an essential, ubiquitous and universal
export machinery for most proteins that integrate into, or translocate through, the plasma …

One of the most salient features of Bacillus subtilis and related bacilli is their natural capacity
to secrete a variety of proteins into their environment, frequently to high concentrations. This …

The timely production of functional proteins is of critical importance for the biological activity
of cells. To reach the functional state, newly synthesized polypeptides have to become …

In bacteria, two major pathways exist to secrete proteins across the cytoplasmic membrane.
The general Secretion route, termed Sec-pathway, catalyzes the transmembrane …

About 25% to 30% of the bacterial proteins function in the cell envelope or outside of the
cell. These proteins are synthesized in the cytosol, and the vast majority is recognized as a …

Bacteria are simple and cost effective hosts for producing recombinant proteins. However,
their physiological features may limit their use for obtaining in native form proteins of some …

Recent years have witnessed major advances in our understanding of the structural basis of
protein aggregation on several fronts. Firstly, high-resolution structural information that …

Molecular chaperones act on non-native proteins in the cell to prevent their aggregation,
premature folding or misfolding. Different chaperones often exert distinct effects, such as …

Protein transport via the Sec translocon represents an evolutionary conserved mechanism
for delivering cytosolically-synthesized proteins to extra-cytosolic compartments. The Sec …

All cells must traffic proteins across their membranes. This essential process is responsible
for the biogenesis of membranes and cell walls, motility and nutrient scavenging and uptake …