Osteoarthritis (OA) is a progressive chronic inflammation that leads to cartilage
degeneration. OA Patients are commonly given pharmacological treatment, but the available …

With the gradual demographic shift toward an aging and obese society, an increasing
number of patients are suffering from bone and cartilage injuries. However, conventional …

Current intra-articular drug delivery methods do not guarantee sufficient drug penetration
into cartilage tissue to reach cell and matrix targets at the concentrations necessary to elicit …

Successful regeneration of cartilage tissue at a clinical scale has been a tremendous
challenge in the past decades. Microcarriers (MCs), usually used for cell and drug delivery …

Abnormal Rac1 signaling is linked to a number of debilitating human diseases, including
cancer, cardiovascular diseases and neurodegenerative disorders. As such, Rac1 …

Due to a blood supply shortage, articular cartilage has a limited capacity for self-healing
once damaged. Articular chondrocytes, cartilage progenitor cells, embryonic stem cells, and …

The proper interactions between blood vessels and neurons are critical for maintaining the
strength of neural circuits and cognitive function. However, the precise molecular events …

Osteoarthritis (OA) in China is gradually becoming an important scientific research area that
has had a significant impact on research and development (R&D) activities in the OA field …

Abstract Changes in the stiffness of chondrocyte extracellular matrix (ECM) are involved in
the pathological progression of osteoarthritis (OA). However, the downstream responses of …

Reduced expression of autophagy regulators has been observed in pathological cartilage in
humans and mice. The present study aimed to investigate the synergistic therapeutic effect …