Epithelial-mesenchymal transition (EMT) is a complex reversible biological process
characterized by the loss of epithelial features and the acquisition of mesenchymal features …

Fibroblasts are crucial components of the skin structure. They were traditionally believed to
maintain the skin's structure by producing extracellular matrix and other elements. Recent …

Renal interstitial fibrosis (RIF) is a significant pathological change in diabetic kidney disease
(DKD) that can be induced by endothelial-to-mesenchymal transition (EndMT) …

Inflammation and fibrosis often occur in the kidney after acute injury, resulting in chronic
kidney disease and consequent renal failure. Recent studies have indicated that …

In systemic sclerosis (SSc, or scleroderma), defective angiogenesis, clinically manifesting
with abnormal capillary architecture and severe capillary reduction, represents a hallmark of …

The bleomycin-induced scleroderma model is a well-established and dependable method
for creating a mouse model of SSc (systemic sclerosis). In the field of skin connective tissue …

Background Systemic sclerosis represents a persistent autoimmune disorder marked with
fibrosis affecting both skin and other organs, which leads to a diminished quality of life and …