Alzheimer's disease (AD) stands as the predominant form of dementia, presenting significant
and escalating global challenges. Its etiology is intricate and diverse, stemming from a …

Phosphoinositide 3-kinases (PI3Ks) control many important aspects of immune cell
development, differentiation, and function. Mammals have eight PI3K catalytic subunits that …

Silver nanoparticles (AgNPs), embedded into a specific polysaccharide (EPS), were
biogenerated by Klebsiella oxytoca DSM 29614 under aerobic (AgNPs-EPSaer) and …

Reduction of amyloid beta (Aβ) has been shown to be effective in treating Alzheimer's
disease (AD), but the underlying assumption that neurons are the main source of pathogenic …

Autophagy, an ancient and highly conserved intracellular degradation process, is viewed as
a critical component of innate immunity because of its ability to deliver cytosolic bacteria to …

NFE2-like basic leucine zipper transcription factor 2 (NFE2L2, also known as NRF2), is a
key transcription factor in the cellular defense against oxidative stress, playing a crucial role …

Autophagy is a fundamental biological process critical to all eukaryotic cellular life. Although
autophagy has been increasingly studied, how its process is precisely coordinated remains …

A cell death pathway, ferroptosis, occurs in conidial cells and is critical for formation and
function of the infection structure, the appressorium, in the rice blast fungus Magnaporthe …

Type 2 diabetes (T2D), a prevalent metabolic disorder lacking effective treatments, is
associated with lysosomal acidification dysfunction, as well as autophagic and mitochondrial …

PANoptosis, a complex form of proinflammatory programmed cell death, including
apoptosis, pyroptosis and necroptosis, has been an emerging concept in recent years that …