Acquired and inherited retinal disorders are responsible for vision loss in an increasing
proportion of individuals worldwide. Photoreceptor (PR) death is central to the vision loss …

Age-related macular degeneration, the leading cause of irreversible visual loss among older
adults in developed countries, is a chronic, multifactorial, and progressive disease with the …

Single-cell RNA sequencing has revolutionized ocular gene expression studies. This
technology has enabled researchers to identify expression signatures for rare cell types and …

Background Advanced age-related macular degeneration (AMD) is a leading cause of
blindness. While around half of the genetic contribution to advanced AMD has been …

Bulk RNA sequencing of a tissue captures the gene expression profile from all cell types
combined. Single-cell RNA sequencing identifies discrete cell-signatures based on …

Nanophthalmos is a rare, potentially devastating eye condition characterized by small eyes
with relatively normal anatomy, a high hyperopic refractive error, and frequent association …

Background and purpose: Primary open-angle glaucoma (POAG) is an optic neuropathy
characterized by death of retinal ganglion cells and atrophy of the optic nerve head. The …

Despite decades of research, knowledge about the genes that are important for
development and function of the mammalian eye and are involved in human eye disorders …

First discovered in a light-sensitive retinal mutant of Drosophila, the transient receptor
potential (TRP) superfamily of non-selective cation channels serve as polymodal cellular …

The development of the vertebrate visual system involves complex morphogenetic
interactions of cells derived from multiple embryonic lineages. Disruptions in this process …