T cell activation is a crucial checkpoint in adaptive immunity, and this activation depends on
the binding parameters that govern the interactions between T cell receptors (TCRs) and …

The value of in silico methods in drug development and evaluation has been demonstrated
repeatedly and convincingly. While their benefits are now unanimously recognized …

Signaling pathways function as the information-passing mechanisms of cells. A number of
databases with extensive manual curation represent the current knowledge base for …

The specialization of cartilage cells, or chondrogenic differentiation, is an intricate and
meticulously regulated process that plays a vital role in both bone formation and cartilage …

Insulin and insulin-like growth factor I (IGF1) influence cancer risk and progression through
poorly understood mechanisms. To better understand the roles of insulin and IGF1 signaling …

Background There are many available software tools for visualization and analysis of
biological networks. Among them, Cytoscape (http://cytoscape. org/) is one of the most …

Networks have become ubiquitous in systems biology. Visualization is a crucial component
in their analysis. However, collaborations within research teams in network biology are …

Despite high prevalence, medical impact and societal burden, anxiety, depression and other
affective disorders remain poorly understood and treated. Clinical complexity and polygenic …

Understanding the molecular mechanisms underlying the connections between genotype
and phenotype in human is one of the most important biological questions. By integrating …

Recent advances in systems biology are shedding a new light on the traditional medicine
research. The systems biology highlights the way each component interacts with each other …