Copper active sites in biology

EI Solomon, DE Heppner, EM Johnston… - Chemical …, 2014 - ACS Publications
On the basis of its generally accessible I/II redox couple and bioavailability, copper plays a
wide variety of roles in nature that mostly involve electron transfer (ET), O 2 binding …

Prophenoloxidase system and its role in shrimp immune responses against major pathogens

P Amparyup, W Charoensapsri… - Fish & Shellfish …, 2013 - Elsevier
The global shrimp industry still faces various serious disease-related problems that are
mainly caused by pathogenic bacteria and viruses. Understanding the host defense …

The prophenoloxidase‐activating system in invertebrates

L Cerenius, K Söderhäll - Immunological reviews, 2004 - Wiley Online Library
A major innate defense system in invertebrates is the melanization of pathogens and
damaged tissues. This important process is controlled by the enzyme phenoloxidase (PO) …

Plastic degradation by insect hexamerins: Near-atomic resolution structures of the polyethylene-degrading proteins from the wax worm saliva

M Spínola-Amilibia, R Illanes-Vicioso, E Ruiz-López… - Science …, 2023 - science.org
Plastic waste management is a pressing ecological, social, and economic challenge. The
saliva of the lepidopteran Galleria mellonella larvae is capable of oxidizing and …

Copper–O 2 reactivity of tyrosinase models towards external monophenolic substrates: molecular mechanism and comparison with the enzyme

M Rolff, J Schottenheim, H Decker… - Chemical Society Reviews, 2011 - pubs.rsc.org
The critical review describes the known dicopper systems mediating the aromatic
hydroxylation of monophenolic substrates. Such systems are of interest as structural and …

Activation of dioxygen by copper metalloproteins and insights from model complexes

DA Quist, DE Diaz, JJ Liu, KD Karlin - JBIC Journal of Biological Inorganic …, 2017 - Springer
Nature uses dioxygen as a key oxidant in the transformation of biomolecules. Among the
enzymes that are utilized for these reactions are copper-containing metalloenzymes, which …

Diverse immune functions of hemocyanins

CJ Coates, J Nairn - Developmental & Comparative Immunology, 2014 - Elsevier
Substantial evidence gathered recently has revealed the multiple functionalities of
hemocyanin. Contrary to previous claims that this ancient protein is involved solely in …

Tyrosinase/catecholoxidase activity of hemocyanins: structural basis and molecular mechanism

H Decker, F Tuczek - Trends in biochemical sciences, 2000 - cell.com
The enzymes tyrosinase, catecholoxidase and hemocyanin all share similar active sites,
although their physiological functions differ. Hemocyanins serve as oxygen carrier proteins …

Phenoloxidases in insect immunity

MR Kanost, MJ Gorman - Insect immunology, 2008 - books.google.com
Phenoloxidases are present as zymogens in insect hemolymph, and they become activated
upon wounding or infection as part of the innate immune response. These enzymes are …

Origin and evolution of arthropod hemocyanins and related proteins

T Burmester - Journal of Comparative Physiology B, 2002 - Springer
Arthropod hemocyanins are large, multimeric,(n× 6) copper-containing proteins that deliver
oxygen in the haemolymph of many chelicerate, crustacean, myriapod, and also possibly …