Immunotherapy has brought a paradigm shift in the treatment of tumors in recent decades.
However, a significant proportion of patients remain unresponsive, largely due to the …

Cancer incidence and mortality are growing worldwide. With a lack of optimal treatments
across many cancer types, there is an unmet need for the development of novel treatment …

Rapamycin is an immunosuppressive drug that is widely used in the postsurgery
management of transplantation. To date, the mechanism by which rapamycin reduces …

Introduction Metabolic rewiring satisfies increased nutritional demands and modulates many
oncogenic processes in tumors. Amino acid metabolism is abnormal in many malignancies …

Metastatic uveal melanoma (UM) is a devastating disease with few treatment options. We
evaluated the safety, tolerability and preliminary activity of arginine depletion using …

Metabolic reprogramming is one of the hallmarks of tumor. Growing evidence suggests
metabolic changes that support oncogenic progression may cause selective vulnerabilities …

Background About 25% of patients with acute hepatitis C virus (HCV) infection show
spontaneous clearance within the first six months of infection but may remain at risk of …

Myeloid cells are a key determinant of tumor progression and patient outcomes in a range of
cancers and are therefore being actively pursued as targets of new immunotherapies. The …

Concerning the progression of societies and the evolution of lifestyle and dietary habits, the
potential for the development of human malignancies, particularly colorectal cancer (CRC) …

Introduction Costimulatory members of the tumor necrosis factor receptor family, such as
OX40 (CD134), provide essential survival and differentiation signals that enhance T cell …