Purines and their derivatives, most notably adenosine and ATP, are the key molecules
controlling intracellular energy homoeostasis and nucleotide synthesis. Besides, these …

Coronaviruses, named for their crown-like spiked surface, are genetically diverse and can
infect multiple animal species, including bats, pigs, cats, rodents, and humans. Aside from …

This review aims to serve as an introduction to the solute carrier proteins (SLC) superfamily
of transporter proteins and their roles in human cells. The SLC superfamily currently …

T cells play a critical role in cancer control, but a range of potent immunosuppressive
mechanisms can be upregulated in the tumor microenvironment (TME) to abrogate their …

Adenosine is an evolutionary ancient metabolic regulator linking energy state to physiologic
processes, including immunomodulation and cell proliferation. Tumors create an adenosine …

Summary Δ 9-tetrahydrocannabinol (THC) and its sibling, cannabidiol (CBD), are produced
by the same Cannabis plant and have similar chemical structures but differ dramatically in …

Extracellular nucleotides, mainly ATP, but also ADP, UTP, UDP and UDP-sugars,
adenosine, and adenine base participate in the “purinergic signalling” pathway, an …

Abstract A3 adenosine receptor (A3AR) is a cell membrane protein, which has been found to
be overexpressed in a large number of cancer types. This receptor plays an important role in …

Ecto-5′-nucleotidase [cluster of differentiation 73 (CD73)] is a ubiquitously expressed
glycosylphosphatidylinositol-anchored glycoprotein that converts extracellular adenosine …

Adenosine (Ado) is a well-studied neurotransmitter, but it also exerts profound immune
regulatory functions. Ado can (i) actively be released by various cells into the tissue …