alpha‐2‐Macroglobulin: a physiological guardian

AA Rehman, H Ahsan, FH Khan - Journal of cellular physiology, 2013 - Wiley Online Library
Alpha macroglobulins are large glycoproteins which are present in the body fluids of both
invertebrates and vertebrates. Alpha‐2‐macroglobulin (α2M), a key member of alpha …

Lactoferrin: An overview of its main functions, immunomodulatory and antimicrobial role, and clinical significance

M Sienkiewicz, A Jaśkiewicz, A Tarasiuk… - Critical reviews in food …, 2022 - Taylor & Francis
Lactoferrin (LF), a glycoprotein found in mucosal secretions, is characterized by a wide
range of functions, including immunomodulatory and anti-inflammatory activities. Moreover …

Elevated tumor LDLR expression accelerates LDL cholesterol-mediated breast cancer growth in mouse models of hyperlipidemia

EJ Gallagher, Z Zelenko, BA Neel, IM Antoniou… - Oncogene, 2017 - nature.com
Obesity is associated with an increase in cancer-specific mortality in women with breast
cancer. Elevated cholesterol, particularly low-density lipoprotein cholesterol (LDL-C), is …

HDL and LDL: potential new players in breast cancer development

L Cedó, ST Reddy, E Mato, F Blanco-Vaca… - Journal of clinical …, 2019 - mdpi.com
Breast cancer is the most prevalent cancer and primary cause of cancer-related mortality in
women. The identification of risk factors can improve prevention of cancer, and obesity and …

[HTML][HTML] Lipid nanoparticles for targeted delivery of anticancer therapeutics: recent advances in development of siRNA and lipoprotein-mimicking nanocarriers

A Yaghmur, J Østergaard, H Mu - Advanced Drug Delivery Reviews, 2023 - Elsevier
The limitations inherent in conventional cancer treatment methods have stimulated recent
efforts towards the design of safe nanomedicines with high efficacy for combating cancer …

Plasma level of LDL-cholesterol at diagnosis is a predictor factor of breast tumor progression

C Rodrigues dos Santos, I Fonseca, S Dias… - BMC cancer, 2014 - Springer
Background Among women, breast cancer (BC) is the leading cancer and the most common
cause of cancer-related death between 30 and 69 years. Although lifestyle and diet are …

Multi-faceted role of LRP1 in the immune system

O Sizova, LS John, Q Ma, JJ Molldrem - Frontiers in immunology, 2023 - frontiersin.org
Graft versus host disease (GVHD) represents the major complication after allogeneic
hematopoietic stem cell transplantation (Allo-SCT). GVHD-prone patients rely on GVHD …

Low-density lipoprotein receptor promotes crosstalk between cell stemness and tumor immune microenvironment in breast cancer: a large data-based multi-omics …

Q Yuan, X Lu, H Guo, J Sun, M Yang, Q Liu… - Journal of Translational …, 2023 - Springer
Background Tumor cells with stemness in breast cancer might facilitate the immune
microenvironment's suppression process and led to anti-tumor immune effects. The primary …

LDL, HDL and endocrine-related cancer: From pathogenic mechanisms to therapies

G Revilla, L Cedó, M Tondo, A Moral, JI Pérez… - Seminars in cancer …, 2021 - Elsevier
Cholesterol is essential for a variety of functions in endocrine-related cells, including
hormone and steroid production. We have reviewed the progress to date in research on the …

Cholesterol homeostasis and cancer: a new perspective on the low-density lipoprotein receptor

J Gu, N Zhu, HF Li, TJ Zhao, CJ Zhang, DF Liao, L Qin - Cellular Oncology, 2022 - Springer
Background Disturbance of cholesterol homeostasis is considered as one of the
manifestations of cancer. Cholesterol plays an essential role in the pleiotropic functions of …