Gradual disclosure of the molecular basis of selective neuronal apoptosis during
neurodegenerative diseases reveals active participation of acetylating and deacetylating …

Histone deacetylase (HDAC) inhibitors have been demonstrated to be beneficial in animal
models of neurodegenerative diseases. Such results were mainly associated with the …

Huntington's disease (HD) is an inherited, progressive neurological disorder that is caused
by a CAG/polyglutamine repeat expansion and for which there is no effective therapy …

Huntington's disease (HD) is a devastating autosomal dominant neurodegenerative disease
caused by a CAG trinucleotide repeat expansion encoding an abnormally long …

Huntington's disease (HD) is caused by an expansion of exonic CAG triplet repeats in the
gene encoding the huntingtin protein (Htt), however, the means by which …

The cause of Huntington's disease is expansion of polyglutamine (polyQ) domain in
huntingtin, which makes this protein both neurotoxic and aggregation prone. Here we …

Huntington's disease (HD) is an autosomal dominant disorder caused by an expansion of
glutamine repeats in ubiquitously distributed huntingtin protein. Recent studies have shown …

In ageing populations, neurodegenerative diseases increase in prevalence, exacting an
enormous toll on individuals and their communities. Multiple complementary experimental …

Previous analyses of gene expression in a mouse model of Huntington's disease (R6/2)
indicated that an N-terminal fragment of mutant huntingtin causes downregulation of striatal …

Protein misfolding is the molecular basis for several human diseases. How the primary
amino acid sequence triggers misfolding and determines the benign or toxic character of the …