Background Opioid-induced hyperalgesia (OIH) is well documented in preclinical studies,
but findings of clinical studies are less consistent. The objective was to undertake a …

In the midst of an epidemic of opioid abuse and overdose-related morbidity and mortality,
the use of opioids remains the most common means of providing analgesia in the …

The visceral analgesic efficacy of erector spinae plane block (ESPB) is still a matter of
debate. This study attempted to investigate the visceral analgesic efficacy of ESPB in clinical …

Background Opioid‐induced hyperalgesia is a state of nociceptive sensitisation secondary
to opioid administration. The objective of this meta‐analysis was to test the hypothesis that …

BACKGROUND: Consecutive exposure to high-dose remifentanil during anesthesia may
induce remifentanil-induced postinfusion hyperalgesia (RPH). Dexmedetomidine, a highly …

Sufentanil, a potent opioid, serves as the first option for perioperative analgesia owing to its
analgesic effect, long duration and stable hemodynamics, whereas its side effects frequently …

Background This meta-analysis aimed to explore the correlation between the different doses
of remifentanil-based anaesthesia and postoperative pain in randomised trials. Methods The …

Chronic pain begins with acute pain. Physicians tend to classify pain by duration (acute vs
chronic) and mechanism (nociceptive, neuropathic and nociplastic). Although this taxonomy …

Intraoperative remifentanil infusion may paradoxically induce post-surgical hyperalgesia.
Dexmedetomidine reportedly reduces opioid-induced hyperalgesia. Nalmefene selectively …

This paper is the fortieth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …