New technologies have enabled the investigation of biology and human health at an
unprecedented scale and in multiple dimensions. These dimensions include a myriad of …

Our understanding of gene expression has changed dramatically over the past decade,
largely catalysed by technological developments. High-throughput experiments …

Genes that are thought to be critical for the survival of organisms or cells are called essential
genes. The prediction of essential genes and their products (essential proteins) is of great …

Essential proteins as a vital part of maintaining the cells' life play an important role in the
study of biology and drug design. With the generation of large amounts of biological data …

Essential genes are critical for the growth and survival of any organism. The machine
learning approach complements the experimental methods to minimize the resources …

Computational methods including centrality and machine learning-based methods have
been proposed to identify essential proteins for understanding the minimum requirements of …

Essential genes contain key information of genomes that could be the key to a
comprehensive understanding of life and evolution. Because of their importance, studies of …

Background Identification of essential proteins plays a significant role in understanding
minimal requirements for the cellular survival and development. Many computational …

A clear perception of gene essentiality in bacterial pathogens is pivotal for identifying drug
targets to combat emergence of new pathogens and antibiotic-resistant bacteria, for …

Bacterial cells are widely used to produce value-added products due to their versatility, ease
of manipulation, and the abundance of genome engineering tools. However, the efficiency of …