Recent antimalarial drug discovery has been a race to produce new medicines that
overcome emerging drug resistance, whilst considering safety and improving dosing …

Infections caused by malaria parasites place an enormous burden on the world's poorest
communities. Breakthrough drugs with novel mechanisms of action are urgently needed. As …

To define cellular immunity to the intracellular pathogen Toxoplasma gondii, we performed a
genome-wide CRISPR loss-of-function screen to identify genes important for (interferon …

Parasitic diseases result in considerable human morbidity and mortality. The continuous
emergence and spread of new drug-resistant parasite strains is an obstacle to controlling …

Patients with haematological malignancies might develop life-threatening toxoplasmosis,
especially after allogeneic haematopoietic stem-cell transplantation (HSCT). Reactivation of …

Toxoplasma gondii is an obligate intracellular zoonotic pathogen capable of infecting almost
all cells of warm-blooded vertebrates. In intermediate hosts, this parasite reproduces …

The current treatments for toxoplasmosis are only active against fast-growing tachyzoites,
present in acute infections, with little effect on slow-growing bradyzoites within tissue cysts …

Identification of drug targets and biochemical investigations on mechanisms of action are
major issues in modern drug development. The present article is a critical review of the …

Novel methods for constructing functionalized 1, 3-diazepine and 1, 4-diazocine derivatives
have been disclosed through phosphine-catalyzed [4+ 3] and [4+ 4] annulations of β …

Previous studies have shown that bicyclic azetidines are potent and selective inhibitors of
apicomplexan phenylalanine tRNA synthetase (PheRS), leading to parasite growth …