Modern antiepileptic drug development has failed to deliver: ways out of the current dilemma

W Löscher, D Schmidt - Epilepsia, 2011 - Wiley Online Library
Despite the development of various new antiepileptic drugs (AEDs) since the early 1990s,
the available evidence indicates that the efficacy and tolerability of drug treatment of …

Epilepsy treatment in adults and adolescents: expert opinion, 2016

JJ Shih, JB Whitlock, N Chimato, E Vargas… - Epilepsy & Behavior, 2017 - Elsevier
Introduction: There are over twenty anti-seizure medications and anti-seizure devices
available commercially in the United States. The multitude of treatment options for seizures …

Guidelines on management of low‐grade gliomas: report of an EFNS–EANO* Task Force

R Soffietti, BG Baumert, L Bello… - European journal of …, 2010 - Wiley Online Library
Background: Diffuse infiltrative low‐grade gliomas of the cerebral hemispheres in the adult
are a group of tumors with distinct clinical, histological and molecular characteristics, and …

Difficulties in treatment and management of epilepsy and challenges in new drug development

A Wahab - Pharmaceuticals, 2010 - mdpi.com
Epilepsy is a serious neurological disorder that affects around 50 million people worldwide.
Almost 30% of epileptic patients suffer from pharmacoresistance, which is associated with …

Antiemetic medication for prevention and treatment of chemotherapy‐induced nausea and vomiting in childhood

RS Phillips, AJ Friend, F Gibson… - Cochrane Database …, 2016 - cochranelibrary.com
Background Nausea and vomiting remain a problem for children undergoing treatment for
malignancies despite new antiemetic therapies. Optimising antiemetic regimens could …

The efficacy and tolerability of levetiracetam in pharmacoresistant epileptic dogs

HA Volk, LA Matiasek, AL Feliu-Pascual, SR Platt… - The Veterinary …, 2008 - Elsevier
Twenty-two dogs with idiopathic epilepsy which were pharmacoresistant to phenobarbitone
and bromide were treated with levetiracetam as an add-on medication. Records of eight …

The social and economic consequences of epilepsy: a controlled national study

P Jennum, J Gyllenborg, J Kjellberg - Epilepsia, 2011 - Wiley Online Library
Purpose: Epilepsy causes a significant burden to patients and to society. We aimed to
calculate the factual excess in direct and indirect costs associated with epilepsy. Methods …

Systems theory: a worldview and/or a methodology aimed at requisite holism/realism of humans' thinking, decisions and action

M Mulej - Systems Research and Behavioral Science: The …, 2007 - Wiley Online Library
Many observers find that humankind is in crisis due to lack of holism and due to too much
reductionism—in human thinking, insight, decision‐making and action—caused by …

[HTML][HTML] Trends in antiepileptic drug utilisation in UK primary care 1993–2008: cohort study using the General Practice Research Database

JM Nicholas, L Ridsdale, MP Richardson, M Ashworth… - Seizure, 2012 - Elsevier
PURPOSE: To describe changes in utilisation of antiepileptic drugs (AED) by people with
epilepsy in the United Kingdom during 1993–2008. METHODS: Cohort study of 63,586 …

Antiepileptic drug combinations—have newer agents altered clinical outcomes?

LJ Stephen, M Forsyth, K Kelly, MJ Brodie - Epilepsy research, 2012 - Elsevier
In 2000, 332 (20.5%) of 1617 patients registered with the Western Infirmary Epilepsy Unit
required antiepileptic drug (AED) polytherapy to remain seizure-free for at least 1 year. The …