Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint destruction,
synovitis, and pannus formation. Gut microbiota dysbiosis may exert direct pathogenic …

Bile acids (BAs), synthesized in the liver and modified by the gut microbiota, have been
widely appreciated not only as simple lipid emulsifiers, but also as complex metabolic …

Objective Bile acids have underlying protective effects on bones structure. Long-term
diabetes also causes skeletal disorders including osteoporosis, Charcot arthropathy and …

OBJECTIVES: Previous studies have not shown any correlation between bile acid
metabolism and bone mineral density (BMD) in women with postmenopausal osteoporosis …

The increasing prevalence of individuals affected by bone pathologies globally has sparked
catastrophic concerns. Ankylosing spondylitis, osteoporosis, rheumatoid arthritis …

A growing body of scientific evidence supports the notion that gut microbiota plays a key role
in the regulation of various physiological and pathological processes related to human …

Scope To analyze the effects of fexaramine (FEX), as an intestinal FXR agonist, on the
modulation of the intestinal microbiota and ileum of mice fed a high‐fat (HF) diet. Methods …

In the recent years, bile acid receptors FXR and GPBAR1 have attracted the interest of
scientific community and companies, as they proved promising targets for the treatment of …

Bile acids play a crucial role in promoting intestinal nutrient absorption and biliary
cholesterol excretion, thereby protecting the liver from cholesterol accumulation and bile …

Background Osteoclast-mediated bone resorption cause bone loss in several bone
diseases. Exosomes have been reported to regulate osteoclast differentiation. M2-polarized …