Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

The collective activity of a population of neurons, beyond the properties of individual cells, is
crucial for many brain functions. A fundamental question is how activity correlations between …

The active electrical properties of dendrites shape neuronal input and output and are
fundamental to brain function. However, our knowledge of active dendrites has been almost …

In 1986, electron microscopy was used to reconstruct by hand the entire nervous system of a
roundworm, the nematode Caenorhabditis elegans. Since this landmark study, high …

Genetically encoded voltage indicators (GEVIs) enable monitoring of neuronal activity at
high spatial and temporal resolution. However, the utility of existing GEVIs has been limited …

Rapid eye movement (REM) sleep is associated with the consolidation of emotional
memories. Yet, the underlying neocortical circuits and synaptic mechanisms remain unclear …

Emotional arousal enhances perception and memory of high-priority information but impairs
processing of other information. Here, we propose that, under arousal, local glutamate levels …

Dendrites have always fascinated researchers: from the artistic drawings by Ramon y Cajal
to the beautiful recordings of today, neuroscientists have been striving to unravel the …

Circuits in the cerebral cortex consist of thousands of neurons connected by millions of
synapses. A precise understanding of these local networks requires relating circuit activity …

The hippocampal system is critical for storage and retrieval of declarative memories,
including memories for locations and events that take place at those locations. Spatial …