Genomic methods for measuring DNA replication dynamics
Genomic DNA replicates according to a defined temporal program in which early-replicating
loci are associated with open chromatin, higher gene density, and increased gene …
loci are associated with open chromatin, higher gene density, and increased gene …
[HTML][HTML] Meiotic recombination mirrors patterns of germline replication in mice and humans
Genetic recombination generates novel trait combinations, and understanding how
recombination is distributed across the genome is key to modern genetics. The PRDM9 …
recombination is distributed across the genome is key to modern genetics. The PRDM9 …
Functional genomic approaches to elucidate the role of enhancers during development
GE Ryan, EK Farley - Wiley Interdisciplinary Reviews: Systems …, 2020 - Wiley Online Library
Successful development depends on the precise tissue‐specific regulation of genes by
enhancers, genetic elements that act as switches to control when and where genes are …
enhancers, genetic elements that act as switches to control when and where genes are …
Using GARDEN-NET and ChAseR to explore human haematopoietic 3D chromatin interaction networks
We introduce an R package and a web-based visualization tool for the representation,
analysis and integration of epigenomic data in the context of 3D chromatin interaction …
analysis and integration of epigenomic data in the context of 3D chromatin interaction …
[HTML][HTML] Chromatin network analyses: towards structure-function relationships in epigenomics
V Pancaldi - Frontiers in Bioinformatics, 2021 - frontiersin.org
Recent technological advances have allowed us to map chromatin conformation and
uncover the genome's spatial organization of the genome inside the nucleus. These …
uncover the genome's spatial organization of the genome inside the nucleus. These …
[HTML][HTML] TAD cliques predict key features of chromatin organization
Background Mechanisms underlying genome 3D organization and domain formation in the
mammalian nucleus are not completely understood. Multiple processes such as …
mammalian nucleus are not completely understood. Multiple processes such as …
Mapping Multi-factor-mediated Chromatin Interactions to Assess Dysregulation of Lung Cancer-related Genes
Y Zhang, J Zhang, W Zhang, M Wang… - Genomics …, 2023 - academic.oup.com
Studies on the lung cancer genome are indispensable for developing a cure for lung cancer.
Whole-genome resequencing, genome-wide association studies, and transcriptome …
Whole-genome resequencing, genome-wide association studies, and transcriptome …
Clustering of strong replicators associated with active promoters is sufficient to establish an early‐replicating domain
Vertebrate genomes replicate according to a precise temporal program strongly correlated
with their organization into A/B compartments. Until now, the molecular mechanisms …
with their organization into A/B compartments. Until now, the molecular mechanisms …
Mapping Multiple Factors Mediated Chromatin Interactions to Assess Regulatory Network and Dysregulation of Lung Cancer-Related Genes
Y Zhang, J Zhang, W Zhang, M Wang, S Wang, Y Xu… - bioRxiv, 2022 - biorxiv.org
Studies on the lung cancer genome are indispensable for developing a cure for lung cancer.
Whole-genome resequencing, genome-wide association studies, and transcriptome …
Whole-genome resequencing, genome-wide association studies, and transcriptome …
Germline DNA replication shapes the recombination landscape in mammals
Genetic recombination generates novel trait combinations and understanding how
recombination is distributed across the genome is key to modern genetics. The PRDM9 …
recombination is distributed across the genome is key to modern genetics. The PRDM9 …