Neutrophils in liver diseases: pathogenesis and therapeutic targets

K Liu, FS Wang, R Xu - Cellular & molecular immunology, 2021 - nature.com
Previously, it was assumed that peripheral neutrophils are a homogeneous population that
displays antimicrobial functions. However, recent data have revealed that neutrophils are …

The pleiotropic immunomodulatory functions of IL-33 and its implications in tumor immunity

C Afferni, C Buccione, S Andreone… - Frontiers in …, 2018 - frontiersin.org
Interleukin-33 (IL-33) is a IL-1 family member of cytokines exerting pleiotropic activities. In
the steady-state, IL-33 is expressed in the nucleus of epithelial, endothelial, and fibroblast …

Mechanisms of action of ruxolitinib in murine models of hemophagocytic lymphohistiocytosis

S Albeituni, KC Verbist, PE Tedrick… - Blood, The Journal …, 2019 - ashpublications.org
Hemophagocytic lymphohistiocytosis (HLH) is an often-fatal disorder characterized by the
overactivation of T cells and macrophages that excessively produce proinflammatory …

[PDF][PDF] Group‐2 innate lymphoid cells promote HCC progression through CXCL2‐neutrophil‐induced immunosuppression

X Xu, L Ye, Q Zhang, H Shen, S Li, X Zhang, M Ye… - …, 2021 - Wiley Online Library
Background and Aims Due to their inherent characteristics, the function of group‐2 innate
lymphoid cells (ILC2s) varies in a context‐dependent manner. ILC2s are involved in certain …

The immune suppressive properties of damage associated molecular patterns in the setting of sterile traumatic injury

E Horner, JM Lord, J Hazeldine - Frontiers in immunology, 2023 - frontiersin.org
Associated with the development of hospital-acquired infections, major traumatic injury
results in an immediate and persistent state of systemic immunosuppression, yet the …

Tissue-dependent adaptations and functions of innate lymphoid cells

JM Murphy, L Ngai, A Mortha, SQ Crome - Frontiers in immunology, 2022 - frontiersin.org
Tissue-resident immune cells reside in distinct niches across organs, where they contribute
to tissue homeostasis and rapidly respond to perturbations in the local microenvironment …

IL-33 in COVID-19: friend or foe?

Y Liang, Y Ge, J Sun - Cellular & Molecular Immunology, 2021 - nature.com
The COVID-19 pandemic, caused by the highly transmissible and pathogenic severe acute
respiratory syndrome coronavirus 2 (SAR-CoV-2), has led to more than 2.7 million deaths …

Bioaccessibility and bioavailability adjusted dietary exposure of cadmium for local residents from a high-level environmental cadmium region

FF Xu, J Song, YQ Li, YF Lai, J Lin, JL Pan… - Journal of Hazardous …, 2021 - Elsevier
The critical health risks caused by cadmium (Cd) via dietary exposure are commonly
assessed by detecting Cd concentrations in foods. Differently, in this study, the …

The janus face of IL-33 signaling in tumor development and immune escape

MR Choi, JA Sosman, B Zhang - Cancers, 2021 - mdpi.com
Simple Summary Interleukin-33 (IL-33) is often released from damaged cells, acting as a
danger signal. IL-33 exerts its function by interacting with its receptor suppression of …

[HTML][HTML] Acetaminophen-induced hepatotoxicity predominantly via inhibiting Nrf2 antioxidative pathway and activating TLR4-NF-κB-MAPK inflammatory response in …

XL Shen, YN Guo, MH Lu, KN Ding, SS Liang… - Ecotoxicology and …, 2023 - Elsevier
To explore the action time and molecular mechanism underlying the effect of
acetaminophen (APAP) on liver injury. APAP was used to establish drug-induced liver injury …