Myelofibrosis (MF) is a myeloproliferative disorder that exhibits considerable biological and
clinical heterogeneity. At the two ends of the disease spectrum are the myelodepletive or …

Introduction Myelofibrosis (MF) is a rare myeloproliferative neoplasm characterized by a
complex symptom profile, cytopenias, splenomegaly, and potential for leukemic progression …

Aging and chronic inflammation are independent risk factors for the development of
atherothrombosis and cardiovascular disease. We hypothesized that aging-associated …

Myeloproliferative neoplasms (MPNs) are chronic cancers characterized by overproduction
of mature blood cells. Their causative somatic mutations, for example, JAK2 V617F, are …

Circulating concentrations of canonically pro‐and anti‐inflammatory cytokines are
commonly measured when evaluating the anti‐inflammatory effects of exercise. An …

Proinflammatory signaling is a hallmark feature of human cancer, including in
myeloproliferative neoplasms (MPNs), most notably myelofibrosis (MF). Dysregulated …

The immune microenvironment is a critical driver and regulator of leukemic progression and
hematological disease. Recent investigations have demonstrated that multiple immune …

Myeloproliferative neoplasms (MPNs), a group of malignant hematological disorders, occur
as a consequence of somatic mutations in the hematopoietic stem cell compartment and …

Platelets play a critical role in hemostasis and thrombus formation. Platelets are small,
anucleate, and short-lived blood cells that are produced by the large, polyploid, and …

The Philadelphia-negative myeloproliferative neoplasms (MPNs) are malignancies of the
hematopoietic stem cell (HSC) arising as a consequence of clonal proliferation driven by …