The peripheral arterial vasodilation hypothesis has been most influential in the field of
cirrhosis and its complications. It has given rise to hundreds of pathophysiological studies in …

Obesity is characterized by a state of chronic, low-grade inflammation. However, excessive
fatty acid release may worsen adipose tissue inflammation and contributes to insulin …

The gastric mucosa maintains structural integrity and function despite continuous exposure
to noxious factors, including 0.1 mol/L HCl and pepsin, that are capable of digesting tissue …

Obesity is a risk factor for developing type 2 diabetes and cardiovascular disease and has
quickly become a worldwide pandemic with few tangible and safe treatment options …

Objective—Atherosclerosis is a chronic inflammatory response of the arterial wall to injury.
High-mobility group box 1 (HMGB1) is a DNA-binding protein, which on release from cells …

Inflammatory mediators in tumor microenvironment influence cancer occurrence, growth and
metastasis through complex signaling networks. Excessive inflammation is closely …

Expression of inducible nitric-oxide (NO) synthase (iNOS) and" high-output" production of
NO by macrophages mediates many cytotoxic actions of these immune cells. However …

Objective—Tumor necrosis factor α (TNF-α), a key proinflammatory cytokine acting on the
endothelium, activates endothelial nitric oxide synthase (eNOS). We have examined the …

Chronic low-grade inflammation is a central component in the pathogenesis of obesity-
related expansion of adipose tissue and complications in other metabolic tissues. Five …

The expression of inducible nitric-oxide synthase (iNOS) and subsequent" high-output" nitric
oxide (NO) production underlies the systemic hypotension, inadequate tissue perfusion, and …