Technological innovations in photochemistry for organic synthesis: flow chemistry, high-throughput experimentation, scale-up, and photoelectrochemistry

L Buglioni, F Raymenants, A Slattery… - Chemical …, 2021 - ACS Publications
Photoinduced chemical transformations have received in recent years a tremendous amount
of attention, providing a plethora of opportunities to synthetic organic chemists. However …

Continuous Flow Upgrading of Selected C2–C6 Platform Chemicals Derived from Biomass

R Gerardy, DP Debecker, J Estager, P Luis… - Chemical …, 2020 - ACS Publications
The ever increasing industrial production of commodity and specialty chemicals inexorably
depletes the finite primary fossil resources available on Earth. The forecast of population …

Photocatalytic systems: reactions, mechanism, and applications

F Mohamadpour, AM Amani - RSC advances, 2024 - pubs.rsc.org
The photocatalytic field revolves around the utilization of photon energy to initiate various
chemical reactions using non-adsorbing substrates, through processes such as single …

A perspective on continuous flow chemistry in the pharmaceutical industry

M Baumann, TS Moody, M Smyth… - … Process Research & …, 2020 - ACS Publications
Continuous flow manufacture is an innovative technology platform, which is gaining
momentum within the pharmaceutical industry. The key advantages of continuous flow …

The evolution of high-throughput experimentation in pharmaceutical development and perspectives on the future

SM Mennen, C Alhambra, CL Allen… - … Process Research & …, 2019 - ACS Publications
High-throughput experimentation (HTE) has revolutionized the pharmaceutical industry,
most notably allowing for rapid screening of compound libraries against therapeutic targets …

Large-scale amidations in process chemistry: practical considerations for reagent selection and reaction execution

J Magano - Organic Process Research & Development, 2022 - ACS Publications
This review describes the practical aspects involved in the implementation of large-scale
amidations in process chemistry. Coupling reagent, base, additive, and solvent selections …

Efficient C(sp3)−H Carbonylation of Light and Heavy Hydrocarbons with Carbon Monoxide via Hydrogen Atom Transfer Photocatalysis in Flow**

F Raymenants, TM Masson… - Angewandte Chemie …, 2023 - Wiley Online Library
Despite their abundance in organic molecules, considerable limitations still exist in synthetic
methods that target the direct C− H functionalization at sp3‐hybridized carbon atoms. This is …

Rapid assessment of the reaction‐condition‐based sensitivity of chemical transformations

L Pitzer, F Schäfers, F Glorius - … Chemie International Edition, 2019 - Wiley Online Library
A systematic, user‐friendly assessment tool that delivers a clear overview of the sensitivity of
reactions to key parameters is highly desirable. Herein, the development of such a method is …

Conjugated porous polymers: incredibly versatile materials with far-reaching applications

D Taylor, SJ Dalgarno, Z Xu, F Vilela - Chemical Society Reviews, 2020 - pubs.rsc.org
Conjugated porous polymers (CPPs) are a class of amorphous polymer networks that are, in
their design, fully cross-linked and fully π-conjugated. The cross-linked nature of CPPs …

Towards the standardization of flow chemistry protocols for organic reactions

CA Hone, CO Kappe - Chemistry‐Methods, 2021 - Wiley Online Library
Flow chemistry studies can sometimes be difficult to reproduce. In this article we provide
guidance to scientists for experimental details that should be considered as part of any …