Asymmetric catalytic multicomponent cascade reactions have become indispensable tools
for enantioselective construction of spirooxindoles. In recent years, a number of successful …

Spirocompounds constitute an important class of organic frameworks enveloping numerous
pharmacological activities, among them, the promising anticancer potential of …

Heterocycles represent the largest diversity of organic compounds with signifcant chemical,
biomedical, and industrial applications. They exist in numerous natural products, dyes, and …

Background: Chalcones are naturally occurring compounds found in various plant species
which are widely used for the traditional popular treatments. Chalcones are distinguished …

An efficient route for the synthesis of novel bis (1, 4-dihydropyrano [2, 3-c] pyrazole-5-
carbonitrile) derivatives is reported. The synthetic pathway involves one pot, synthesis of bis …

A new series of isoxazolyl and thiazolyl urea derivatives was synthesized, fully characterized
and evaluated in vitro as anticancer agents. The chemistry involves a facile protocol for the …

The first catalytic enantioselective construction of biologically important tetrahydroquinolin-5-
one-based spirooxindole has been developed via a chiral cinchona alkaloid catalyzed …

A simple, and efficient procedure has been developed for the synthesis of novel 2-(4-
(hexahydroquinolin-4-yl) phenoxy)-N-arylacetamides and thieno [3′, 2′: 5, 6] pyrimido [1 …

Two novel chemotherapeutic chalcones were synthesized and their structures were
confirmed by different spectral tools. Theoretical studies such as molecular modeling were …

The cyclocondensation reaction of aldehydes with dimedone and bis (6‐aminopyrimidin‐4‐
one) in acetic acid led to the formation of the corresponding bis (pyrimido [4, 5‐b] quinoline …