Background Vasculogenic mimicry (VM) is a recently discovered angiogenetic process
found in many malignant tumors, and is different from the traditional angiogenetic process …

Distinct from classical tumor angiogenesis, vasculogenic mimicry (VM) provides a blood
supply for tumor cells independent of endothelial cells. VM has two distinct types, namely …

Simple Summary Trastuzumab is a humanized antibody that has significantly improved the
management and treatment outcomes of patients with cancers that overexpress HER2 …

The actin cytoskeleton plays a crucial role in many cellular processes while its
reorganization is important in maintaining cell homeostasis. However, in the case of cancer …

Cancer stem cells (CSCs) are a small subpopulation of cells within a tumor that can both self‐
renew and differentiate into other cell types forming the heterogeneous tumor bulk. Since …

Tumor cell vasculogenic mimicry (VM), also dubbed vascular mimicry, describes the
plasticity of aggressive cancer cells forming de novo vascular networks and is associated …

In solid tumors, vasculogenic mimicry (VM) is the formation of vascular structures by cancer
cells, allowing to generate a channel-network able to transport blood and tumor cells. While …

Breast cancer (BC) is the most frequent cancer among women worldwide and is the leading
cause of cancer-related deaths in women. Cancer cells with stem cell-like features and …

Abstract Type IIA topoisomerase (TOP2A) is significantly associated with malignant tumor
development, invasion, treatment and its prognosis, and has been shown to be a therapeutic …

Vascular mimicry is induced by a wide array of genes with functions related to cancer
stemness, hypoxia, angiogenesis and autophagy. Vascular mimicry competent (VM …