NADPH oxidases: from molecular mechanisms to current inhibitors

A Cipriano, M Viviano, A Feoli, C Milite… - Journal of medicinal …, 2023 - ACS Publications
NADPH oxidases (NOXs) form a family of electron-transporting membrane enzymes whose
main function is reactive oxygen species (ROS) generation. Strong evidence suggests that …

Endothelial and vascular smooth muscle dysfunction in hypertension

MG de Oliveira, W Nadruz Jr, FZ Monica - Biochemical pharmacology, 2022 - Elsevier
The development of essential hypertension involves several factors. Vascular dysfunction,
characterized by endothelial dysfunction, low-grade inflammation and structural remodeling …

LRRK2 regulates production of reactive oxygen species in cell and animal models of Parkinson's disease

MT Keeney, EM Rocha, EK Hoffman… - Science Translational …, 2024 - science.org
Oxidative stress has long been implicated in Parkinson's disease (PD) pathogenesis,
although the sources and regulation of reactive oxygen species (ROS) production are poorly …

PARK7/DJ-1 in microglia: implications in Parkinson's disease and relevance as a therapeutic target

F Lind-Holm Mogensen, A Scafidi, A Poli… - Journal of …, 2023 - Springer
Microglia are the immune effector cells of the brain playing critical roles in immune
surveillance and neuroprotection in healthy conditions, while they can sustain …

[HTML][HTML] Rebalancing NOX2/Nrf2 to limit inflammation and oxidative stress across gut-brain axis in migraine

A Ardizzone, AP Capra, A Repici, M Lanza… - Free Radical Biology …, 2024 - Elsevier
Migraine is one of the most common neurological illnesses, and it is characterized by
complicated neurobiology. It was confirmed the influence of inflammation and oxidative …

Structure, activation, and regulation of NOX2: at the crossroad between the innate immunity and oxidative stress-mediated pathologies

C Nocella, A D'Amico, V Cammisotto, S Bartimoccia… - Antioxidants, 2023 - mdpi.com
Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) is a multisubunit
enzyme complex that participates in the generation of superoxide or hydrogen peroxide …

NOX2-TRPM2 coupling promotes Zn2+ inhibition of complex III to exacerbate ROS production in a cellular model of Parkinson's disease

M AlAhmad, H Isbea, E Shitaw, F Li… - Scientific Reports, 2024 - nature.com
Reactive oxygen species (ROS) serve vital physiological functions, but aberrant ROS
production contributes to numerous diseases. Unfortunately, therapeutic progress targeting …

[HTML][HTML] NOX-induced oxidative stress is a primary trigger of major neurodegenerative disorders

Y Zilberter, DR Tabuena, M Zilberter - Progress in Neurobiology, 2023 - Elsevier
Neurodegenerative diseases (NDDs) causing cognitive impairment and dementia are
difficult to treat due to the lack of understanding of primary initiating factors. Meanwhile …

Microalgae as a potential therapeutic drug candidate for neurodegenerative diseases

RP Parameswari, T Lakshmi - Journal of Biotechnology, 2022 - Elsevier
Microalgae are highly photosynthetic unicellular organism that have increased demand in
the recent days owing to the presence of valuable cellular metabolites. They are ubiquitous …

Neuronal oxidative stress promotes α-synuclein aggregation in vivo

SJ Won, R Fong, N Butler, J Sanchez, Y Zhang… - Antioxidants, 2022 - mdpi.com
Both genetic and environmental factors increase risk for Parkinson's disease. Many of the
known genetic factors influence α-synuclein aggregation or degradation, whereas most of …