[HTML][HTML] The connexin 43 C-terminus: A tail of many tales
Connexins are chordate gap junction channel proteins that, by enabling direct
communication between the cytosols of adjacent cells, create a unique cell signalling …
communication between the cytosols of adjacent cells, create a unique cell signalling …
Insights into the role of connexins and specialized intercellular communication pathways in breast cancer: mechanisms and applications
MRC Mateos, P Carpintero-Fernández… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Gap junctions, membrane-based channels comprised of connexin proteins (Cxs), facilitate
direct communication among neighbouring cells and between cells and the extracellular …
direct communication among neighbouring cells and between cells and the extracellular …
[HTML][HTML] Na+/H+ exchanger NHE1 regulation modulates metastatic potential and epithelial-mesenchymal transition of triple-negative breast cancer cells
SR Amith, JM Wilkinson, L Fliegel - Oncotarget, 2016 - ncbi.nlm.nih.gov
In triple-negative breast cancer (TNBC), the high recurrence rate, increased invasion and
aggressive metastatic formation dictate patient survival. We previously demonstrated a …
aggressive metastatic formation dictate patient survival. We previously demonstrated a …
Cx43 expression correlates with breast cancer metastasis in MDA-MB-231 cells in vitro, in a mouse xenograft model and in human breast cancer tissues
JM Kazan, J El-Saghir, J Saliba, A Shaito… - Cancers, 2019 - mdpi.com
Connexins regulate multiple cellular functions and are considered tumor suppressors.
Connexin43 (Cx43) is frequently down-regulated in breast tumors. However, Cx43 …
Connexin43 (Cx43) is frequently down-regulated in breast tumors. However, Cx43 …
Gene expression profiling in peripheral blood cells and synovial membranes of patients with psoriatic arthritis
M Dolcino, A Ottria, A Barbieri, G Patuzzo, E Tinazzi… - PloS one, 2015 - journals.plos.org
Background Psoriatic arthritis (PsA) is an inflammatory arthritis whose pathogenesis is
poorly understood; it is characterized by bone erosions and new bone formation. The …
poorly understood; it is characterized by bone erosions and new bone formation. The …
Connexins: junctional and non-junctional modulators of proliferation
T Aasen - Cell and tissue research, 2015 - Springer
Mounting evidence indicates that dysregulation of gap junctions and their structural subunits—
connexins—often occurs in, and sometimes causes, a variety of proliferative disorders …
connexins—often occurs in, and sometimes causes, a variety of proliferative disorders …
Targeting connexin 43 with α–connexin carboxyl-terminal (ACT1) peptide enhances the activity of the targeted inhibitors, tamoxifen and lapatinib, in breast cancer …
CL Grek, JM Rhett, JS Bruce, MA Abt, GS Ghatnekar… - BMC cancer, 2015 - Springer
Background Treatment failure is a critical issue in breast cancer and identifying useful
interventions that optimize current cancer therapies remains a critical unmet need …
interventions that optimize current cancer therapies remains a critical unmet need …
Connexin43 carboxyl-terminal domain directly interacts with β-catenin
G Spagnol, AJ Trease, L Zheng, M Gutierrez… - International journal of …, 2018 - mdpi.com
Activation of Wnt signaling induces Connexin43 (Cx43) expression via the transcriptional
activity of β-catenin, and results in the enhanced accumulation of the Cx43 protein and the …
activity of β-catenin, and results in the enhanced accumulation of the Cx43 protein and the …
Connexin's connection in breast cancer growth and progression
D Banerjee - International journal of cell biology, 2016 - Wiley Online Library
Gap junctions are cell‐to‐cell junctions that are located in the basolateral surface of two
adjoining cells. A gap junction channel is composed of a family of proteins called connexins …
adjoining cells. A gap junction channel is composed of a family of proteins called connexins …