The spectrum of latent tuberculosis: rethinking the biology and intervention strategies
Immunological tests provide evidence of latent tuberculosis in one third of the global
population, which corresponds to more than two billion individuals. Latent tuberculosis is …
population, which corresponds to more than two billion individuals. Latent tuberculosis is …
Bacterial growth and cell division: a mycobacterial perspective
EC Hett, EJ Rubin - Microbiology and Molecular Biology Reviews, 2008 - Am Soc Microbiol
The genus Mycobacterium is best known for its two major pathogenic species, M.
tuberculosis and M. leprae, the causative agents of two of the world's oldest diseases …
tuberculosis and M. leprae, the causative agents of two of the world's oldest diseases …
Flux balance analysis of biological systems: applications and challenges
Abstract Systems level modelling and simulations of biological processes are proving to be
invaluable in obtaining a quantitative and dynamic perspective of various aspects of cellular …
invaluable in obtaining a quantitative and dynamic perspective of various aspects of cellular …
Antituberculosis drugs: ten years of research
YL Janin - Bioorganic & medicinal chemistry, 2007 - Elsevier
Tuberculosis is today amongst the worldwide health threats. As resistant strains of
Mycobacterium tuberculosis have slowly emerged, treatment failure is too often a fact …
Mycobacterium tuberculosis have slowly emerged, treatment failure is too often a fact …
Interpreting Expression Data with Metabolic Flux Models: Predicting Mycobacterium tuberculosis Mycolic Acid Production
Metabolism is central to cell physiology, and metabolic disturbances play a role in numerous
disease states. Despite its importance, the ability to study metabolism at a global scale using …
disease states. Despite its importance, the ability to study metabolism at a global scale using …
Physiology of mycobacteria
Mycobacterium tuberculosis is a prototrophic, metabolically flexible bacterium that has
achieved a spread in the human population that is unmatched by any other bacterial …
achieved a spread in the human population that is unmatched by any other bacterial …
Flux balance analysis in the era of metabolomics
Flux balance analysis (FBA) has emerged as an effective means to analyse biological
networks in a quantitative manner. Much progress has been made on the extension of FBA …
networks in a quantitative manner. Much progress has been made on the extension of FBA …
Investigating the metabolic capabilities of Mycobacterium tuberculosis H37Rv using the in silico strain iNJ 661 and proposing alternative drug targets
N Jamshidi, BØ Palsson - BMC systems biology, 2007 - Springer
Background: Mycobacterium tuberculosis continues to be a major pathogen in the third
world, killing almost 2 million people a year by the most recent estimates. Even in …
world, killing almost 2 million people a year by the most recent estimates. Even in …
targetTB: A target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis
Background Tuberculosis still remains one of the largest killer infectious diseases,
warranting the identification of newer targets and drugs. Identification and validation of …
warranting the identification of newer targets and drugs. Identification and validation of …
GSMN-TB: a web-based genome-scale network model of Mycobacterium tuberculosismetabolism
Background An impediment to the rational development of novel drugs against tuberculosis
(TB) is a general paucity of knowledge concerning the metabolism of Mycobacterium …
(TB) is a general paucity of knowledge concerning the metabolism of Mycobacterium …