Regulation of placental development and its impact on fetal growth—new insights from mouse models

L Woods, V Perez-Garcia, M Hemberger - Frontiers in endocrinology, 2018 - frontiersin.org
The placenta is the chief regulator of nutrient supply to the growing embryo during gestation.
As such, adequate placental function is instrumental for developmental progression …

Reconciling the distinct roles of angiogenic/anti-angiogenic factors in the placenta and maternal circulation of normal and pathological pregnancies

A Umapathy, LW Chamley, JL James - Angiogenesis, 2020 - Springer
A branched vascular network is crucial to placental development and is dependent on
factors such as vascular endothelial growth factor (VEGF), placental growth factor (PlGF) …

[HTML][HTML] Maternal sildenafil for severe fetal growth restriction (STRIDER): a multicentre, randomised, placebo-controlled, double-blind trial

A Sharp, C Cornforth, R Jackson, J Harrold… - The Lancet Child & …, 2018 - thelancet.com
Background Severe early-onset fetal growth restriction can lead to a range of adverse
outcomes including fetal or neonatal death, neurodisability, and lifelong risks to the health of …

Placental adaptations in growth restriction

S Zhang, TRH Regnault, PL Barker, KJ Botting… - Nutrients, 2015 - mdpi.com
The placenta is the primary interface between the fetus and mother and plays an important
role in maintaining fetal development and growth by facilitating the transfer of substrates and …

Angiogenesis in the placenta: the role of reactive oxygen species signaling

RD Pereira, NE De Long, RC Wang… - BioMed research …, 2015 - Wiley Online Library
Proper placental development and function are central to the health of both the mother and
the fetus during pregnancy. A critical component of healthy placental function is the proper …

[HTML][HTML] Animal models of fetal growth restriction: Considerations for translational medicine

AM Swanson, AL David - Placenta, 2015 - Elsevier
Fetal growth restriction (FGR) is the failure of a fetus to reach its full genetic growth potential.
It occurs in up to 8% of pregnancies, and after premature birth is the second leading cause …

MicroRNA–mRNA networks in pregnancy complications: A comprehensive downstream analysis of potential biomarkers

A Ali, F Hadlich, MW Abbas, MA Iqbal… - International journal of …, 2021 - mdpi.com
Pregnancy complications are a major cause of fetal and maternal morbidity and mortality in
humans. The majority of pregnancy complications initiate due to abnormal placental …

Human chorionic villous differentiation and placental development

J Kojima, M Ono, N Kuji, H Nishi - International Journal of Molecular …, 2022 - mdpi.com
In humans, the placenta provides the only fetomaternal connection and is essential for
establishing a pregnancy as well as fetal well-being. Additionally, it allows maternal …

Functionally integrating nanoparticles alleviate deep vein thrombosis in pregnancy and rescue intrauterine growth restriction

J Cheng, S Zhang, C Li, K Li, X Jia, Q Wei, H Qi… - Nature …, 2022 - nature.com
There is still unmet demand for effective, safe, and patient-friendly anti-thrombotics to treat
deep vein thrombosis (DVT) during pregnancy. Here we first engineer a bioactive …

The role of plasminogen activator inhibitor-1 in gynecological and obstetrical diseases: An update review

J Zhai, Z Li, Y Zhou, X Yang - Journal of reproductive immunology, 2022 - Elsevier
In a normal pregnancy, maternal circulatory system presents a hypercoagulable state due to
the effect of hormone secretion. Even minor variations in fibrinolytic system could lead to …