Gut-liver-brain axis is a three-way highway of information interaction system among the
gastrointestinal tract, liver, and nervous systems. In the past few decades, breakthrough …

Alzheimer's disease (AD) is a neurodegenerative disease with unknown pathogenesis and
complex pathological manifestations. At present, a large number of studies on targeted …

The precise regulation of gene expression is fundamental to neurodevelopment, plasticity
and cognitive function. Although several studies have profiled transcription in the developing …

Primate genomics holds the key to understanding fundamental aspects of human evolution
and disease. However, genetic diversity and functional genomics data sets are currently …

Human-specific genomic changes contribute to the unique functionalities of the human
brain,,,–. The cellular heterogeneity of the human brain, and the complex regulation of gene …

Neurodegenerative diseases encompass a heterogeneous group of conditions
characterised by the progressive degeneration of the structure and function of the central or …

Imprinting is a critical part of normal embryonic development in mammals, controlled by
defined parent-of-origin (PofO) differentially methylated regions (DMRs) known as imprinting …

Epigenetics research in evolutionary biology encompasses a variety of research areas, from
regulation of gene expression to inheritance of environmentally mediated phenotypes. Such …

The size of the cerebral cortex increases dramatically across amniotes, from reptiles to great
apes. This is primarily due to different numbers of neurons and glial cells produced during …

We present haplotype-resolved reference genomes and comparative analyses of six ape
species, namely: chimpanzee, bonobo, gorilla, Bornean orangutan, Sumatran orangutan …