Muscular dystrophies and congenital myopathies arise from specific genetic mutations
causing skeletal muscle weakness that reduces quality of life. Muscle health relies on …

Mutations in the skeletal muscle α-actin gene (ACTA1) cause a range of congenital
myopathies characterised by muscle weakness and specific skeletal muscle structural …

The primary muscle disorders are a diverse group of diseases caused by various defective
structural proteins, abnormal signaling molecules, enzymes and proteins involved in …

Background To construct gene co-expression networks, it is necessary to evaluate the
correlation between different gene expression profiles. However, commonly used correlation …

The precise assembly of the highly organized filament systems found in muscle is critically
important for its function. It has been hypothesized that nebulin, a giant filamentous protein …

Nemaline myopathy (NM) is one of the most common non-dystrophic genetic muscle
disorders. NM is often associated with mutations in the NEB gene. Even though the exact …

The origin of the pathogenic endothelial cells in common infantile hemangioma is unknown.
We show here that the transcriptomes of human placenta and infantile hemangioma are …

Background: Previous immunohistochemical studies of muscle from patients with inclusion
body myositis and polymyositis found many more T cells than B cells, suggesting a role for …

Skeletal muscle differentiation is a complex, highly coordinated process that relies on
precise temporal gene expression patterns. To better understand this cascade of …

Background Facioscapulohumeral muscular dystrophy (FSHD) is one of the most common
muscular dystrophies and is characterized by a non-conventional genetic mechanism …