The integrative physiology of the left ventricle and systemic circulation is fundamental to our
understanding of advanced heart failure and cardiogenic shock. In simplest terms, any …

Degenerative aortic valve stenosis is the most common primary valve disease and a
significant cause of cardiovascular morbidity and mortality. In an era when new techniques …

Aims Although an association between the systemic circulation and transaortic flow rate
(TFR) is frequently hypothesized in patients with aortic stenosis (AS), it has not been …

The central aortic pressure waveform, while simple in form, is complex in its physiological
interpretation. Although general agreement has been reached on the contour and …

Background: Calcific aortic stenosis (AS) involves progressive valve narrowing and
increased left ventricle (LV) afterload. Transcatheter aortic valve implantation (TAVI) offers …

Aortic stenosis (AS) once was conceptualized as a mechanical problem with a fixed left
ventricular (LV) afterload because of an obstructive valve. With time, there has been growing …