Cancer treatment and pharmaceutical development require targeted treatment and less toxic
therapeutic intervention to achieve real progress against this disease. In this scenario …

Genome-scale metabolic models (GEMs) are effective tools for metabolic engineering and
have been widely used to guide cell metabolic regulation. However, the single gene–protein …

Abstract SEIR (Susceptible–Exposed–Infected–Recovered) approach is a classic modeling
method that is frequently used to study infectious diseases. However, in the vast majority of …

Hypertension is a multifactorial disease arising from complex pathophysiological pathways.
Individual characteristics of patients result in different responses to various classes of …

We describe a web-based tool, MakeSBML (https://sys-bio. github. io/makesbml/), that
provides an installation-free application for creating, editing, and searching the Biomodels …

Despite their astonishing biological diversity, surprisingly few shared traits connect all or
nearly all living organisms. Aging, ie, the progressive and irreversible decline in the function …

Ferroptosis is a regulated cell death process characterized by iron ion catalysis and reactive
oxygen species, leading to lipid peroxidation. This mechanism plays a crucial role in age …

Earlier studies aimed at investigating the metabolism of endogenous nucleoside
triphosphates in synchronous cultures of E. coli cells revealed an auto-oscillatory mode of …

Context-specific genome-scale model (CS-GSM) reconstruction is becoming an efficient
strategy for integrating and cross-comparing experimental multi-scale data to explore the …

Biotechnology continues to drive innovation in the production of pharmaceuticals, biofuels,
and other valuable compounds, leveraging the power of microbial systems for enhanced …