Selective autophagy has emerged as a major quality control pathway that surgically
removes damaged or unwanted macromolecules to maintain cellular health. Defects in …

The endoplasmic reticulum (ER) is a dynamic organelle and a reliable performer for
precisely folded proteins. To maintain its function and integrity, arrays of sensory and quality …

Eukaryotes have evolved various quality control mechanisms to promote proteostasis in the
endoplasmic reticulum (ER). Selective removal of certain ER domains via autophagy …

Background Autophagy and ER stress are involved in maintaining some well-orchestrated
mechanisms aimed at either restoring cellular homeostasis or performing cell death …

Objective: This study aimed to explore the underlying mechanism of miR-375 in
exacerbating osteoarthritis (OA). Results: MiR-375 expression were upregulated in OA …

Lysosomal degradation of the endoplasmic reticulum (ER) and its components through the
autophagy pathway has emerged as a major regulator of ER proteostasis. Commonly …

Deubiquitinating enzymes (DUBs) serve to maintain cellular homeostasis via protein
ubiquitination and exert diverse regulatory functions in cancers and other diseases. Much …

Background Ferroptosis, a form of regulated cell death, is an important topic in the field of
cancer research. However, the signalling pathways and factors that sensitise tumour cells to …

Viruses employ various evasion strategies to establish prolonged infection, with evasion of
innate immunity being particularly crucial. Porcine reproductive and respiratory syndrome …

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), the prime causes of
morbidity and mortality in critically ill patients, are usually treated by general supportive …