Efficient and regulated nucleocytoplasmic trafficking of macromolecules to the correct
subcellular compartment is critical for proper functions of the eukaryotic cell. The majority of …

The assembly of ribosomal subunits is a highly orchestrated process that involves a huge
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …

Ribosomes, which synthesize the proteins of a cell, comprise ribosomal RNA and ribosomal
proteins, which coassemble hierarchically during a process termed ribosome biogenesis …

The ribosome is an ancient molecular fossil that provides a telescope to the origins of life.
Made from RNA and protein, the ribosome translates mRNA to coded protein in all living …

Eukaryotic ribosome synthesis is a complex, energy-consuming process that takes place
across the nucleolus, nucleoplasm and cytoplasm and requires more than 200 conserved …

The biogenesis of eukaryotic ribosomes is a complicated process during which the
transcription, modification, folding, and processing of the rRNA is coupled with the ordered …

The dichotomy that separates prokaryotic from eukaryotic cells runs deep. The transition
from pro-to eukaryote evolution is poorly understood due to a lack of reliable intermediate …

The last steps in mRNA export and remodeling are performed by the Nup82 complex, a
large conserved assembly at the cytoplasmic face of the nuclear pore complex (NPC). By …

The advent of RNA-sequencing (RNA-Seq) technologies has markedly improved our
knowledge and expanded the compendium of small non-coding RNAs, most of which derive …

Ribosome biogenesis requires the intertwined processes of folding, modification, and
processing of ribosomal RNA, together with binding of ribosomal proteins. In eukaryotic …