Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

AMPA receptors (AMPARs) mediate the majority of fast excitatory synaptic transmission in
the brain. Dynamic changes in neuronal synaptic efficacy, termed synaptic plasticity, are …

After endocytosis, most membrane proteins and lipids return to the cell surface, but some
membrane components are delivered to late endosomes or the Golgi. We now understand …

The ADP-ribosylation factor (ARF) small GTPases regulate vesicular traffic and organelle
structure by recruiting coat proteins, regulating phospholipid metabolism and modulating the …

The endosomal system is expansive and complex, characterized by swift morphological
transitions, dynamic remodeling of membrane constituents, and intracellular positioning …

The plasma membrane and the underlying cortical actin cytoskeleton undergo continuous
dynamic interplay that is responsible for many essential aspects of cell physiology …

To ensure that extracellular stimuli are translated into intracellular signals of appropriate
magnitude and specificity, most signaling cascades are tightly regulated. One of the major …

Endocytosis, phagocytosis, and macropinocytosis are fundamental processes that enable
cells to sample their environment, eliminate pathogens and apoptotic bodies, and regulate …

Adaptors select cargo for inclusion into coated vesicles in the late secretory and endocytic
pathways. Although originally there were thought to be just two adaptors, AP-1 and AP-2, it …

Small G proteins play a central role in the organization of the secretory and endocytic
pathways. The majority of such small G proteins are members of the Rab family, which are …