Small molecule drugs that covalently bind irreversibly to their target proteins have several
advantages over conventional reversible inhibitors. They include increased duration of …

Nitriles have broad applications in medicinal chemistry, with more than 60 small molecule
drugs on the market containing the cyano functional group. In addition to the well-known …

In the field of drug discovery, the nitrile group is well represented among drugs and
biologically active compounds. It can form both non-covalent and covalent interactions with …

Covalent inhibitors are assuming central importance in drug discovery projects, especially in
this pandemic scenario. Many research groups have focused their attention on inhibiting …

Human cathepsin K (CatK) stands out as a promising target for the treatment of
osteoporosis, considering its role in degrading the bone matrix. Given the small and shallow …

Peptidomimetics of the class of dipeptidyl nitrile analog peptoids were synthesized as
inhibitors of mammalian cysteine proteases of the papain superfamily. The dipeptidyl nitrile …

A large family of enzymes with the function of hydrolyzing peptide bonds, called peptidases
or cysteine proteases (CPs), are divided into three categories according to the peptide chain …

Human African and American trypanosomiasis are the vector-borne parasitic diseases that
have killed millions of people early, and many people are yet suffering from these neglected …

CCovalent inhibitors are being used more frequently in drug discovery and is expected to
revolutionize how enzyme inhibitors and receptor modulators are created in the future. More …

Differential scanning fluorimetry (DSF) is a widely used biophysical technique with
applications to drug discovery and protein biochemistry. DSF experiments are commonly …