An abundance of evidence shows supporting roles for tetraspanin proteins in human cancer.
Many studies show that the expression of tetraspanins correlates with tumour stage, tumour …

Pancreatic cancer (PaCa) has the highest death rate and incidence is increasing. Poor
prognosis is due to late diagnosis and early metastatic spread, which is ascribed to a minor …

Tspan8 and CD151 are metastasis-promoting tetraspanins and a knockdown (kd) of Tspan8
or CD151 and most pronounced of both tetraspanins affects the metastatic potential of the …

Despite critical roles in development and cancer, the mechanisms that specify invasive
cellular behavior are poorly understood. Through a screen of transcription factors in …

TSPAN family of proteins are generally considered to assemble as multimeric complexes on
the plasma membrane. Our previous work uncovered that TSPAN8 can translocate into the …

Pancreatic adenocarcinoma (PaCa) being the deadliest cancer is partly due to early
metastatic spread. Thus, we searched for PaCa‐initiating cell (PaCIC) markers with …

Hepatocellular carcinoma (HCC) is characterized by high prevalence, morbidity, and
mortality. Liver cancer is the sixth most common cancer worldwide; and its subtype, HCC …

Tetraspanin 8 (TSPAN8) is a member of the tetraspanin superfamily that forms TSPAN8-
mediated protein complexes by interacting with themselves and other various cellular …

Aims: This study was designed to investigate the effects of Tetraspanin 8 (TSPAN8)
overexpression and TSPAN8 suppression on gastric cancer cell proliferation and invasion …

Aim CD151 and Tspan8 are metastasis-promoting tetraspanins. To define whether Tspan8
and CD151 fulfil redundant or additive activities, Tspan8 and CD151 were stably knocked …