The role of opioid receptors in immune system function
TK Eisenstein - Frontiers in immunology, 2019 - frontiersin.org
Research on the effects of opioids on immune responses was stimulated in the 1980s by the
intersection of use of intravenous heroin and HIV infection, to determine if opioids were …
intersection of use of intravenous heroin and HIV infection, to determine if opioids were …
Innate immunity and neuroinflammation
Inflammation of central nervous system (CNS) is usually associated with trauma and
infection. Neuroinflammation occurs in close relation to trauma, infection, and …
infection. Neuroinflammation occurs in close relation to trauma, infection, and …
Opioid-induced gut microbial disruption and bile dysregulation leads to gut barrier compromise and sustained systemic inflammation
Morphine and its pharmacological derivatives are the most prescribed analgesics for
moderate to severe pain management. However, chronic use of morphine reduces …
moderate to severe pain management. However, chronic use of morphine reduces …
Gut homeostasis, microbial dysbiosis, and opioids
Gut homeostasis plays an important role in maintaining animal and human health. The
disruption of gut homeostasis has been shown to be associated with multiple diseases. The …
disruption of gut homeostasis has been shown to be associated with multiple diseases. The …
The interplay between chronic pain, opioids, and the immune system
V Malafoglia, S Ilari, L Vitiello, M Tenti… - The …, 2022 - journals.sagepub.com
Chronic pain represents one of the most serious worldwide medical problems, in terms of
both social and economic costs, often causing severe and intractable physical and …
both social and economic costs, often causing severe and intractable physical and …
Toll-like receptor 3 activation selectively reverses HIV latency in microglial cells
D Alvarez-Carbonell, Y Garcia-Mesa, S Milne, B Das… - Retrovirology, 2017 - Springer
Background Multiple toll-like receptors (TLRs) are expressed in cells of the monocytic
lineage, including microglia, which constitute the major reservoir for human …
lineage, including microglia, which constitute the major reservoir for human …
Cocaine-mediated induction of microglial activation involves the ER stress-TLR2 axis
Background Neuroinflammation associated with advanced human immunodeficiency virus
(HIV)-1 infection is often exacerbated by chronic cocaine abuse. Cocaine exposure has …
(HIV)-1 infection is often exacerbated by chronic cocaine abuse. Cocaine exposure has …
Morphine‐mediated release of miR‐138 in astrocyte‐derived extracellular vesicles promotes microglial activation
Opioids, such as morphine, are the mainstay for the management of postsurgical pain. Over
the last decade there has been a dramatic increase in deaths related to opioid overdose …
the last decade there has been a dramatic increase in deaths related to opioid overdose …
Microglia express mu opioid receptor: insights from transcriptomics and fluorescent reporter mice
Background: Microglia activation contributes to chronic pain and to the adverse effects of
opiate use such as analgesic tolerance and opioid-induced hyperalgesia. Both mu opioid …
opiate use such as analgesic tolerance and opioid-induced hyperalgesia. Both mu opioid …
The impact of substance abuse on HIV-mediated neuropathogenesis in the current ART era
V Chilunda, TM Calderon, P Martinez-Aguado… - Brain research, 2019 - Elsevier
Approximately 37 million people worldwide are infected with human immunodeficiency virus
(HIV). One highly significant complication of HIV infection is the development of HIV …
(HIV). One highly significant complication of HIV infection is the development of HIV …