Organization of mammalian locomotor rhythm and pattern generation
Central pattern generators (CPGs) located in the spinal cord produce the coordinated
activation of flexor and extensor motoneurons during locomotion. Previously proposed …
activation of flexor and extensor motoneurons during locomotion. Previously proposed …
Organization of the mammalian locomotor CPG: review of computational model and circuit architectures based on genetically identified spinal interneurons
IA Rybak, KJ Dougherty, NA Shevtsova - ENeuro, 2015 - eneuro.org
The organization of neural circuits that form the locomotor central pattern generator (CPG)
and provide flexor–extensor and left–right coordination of neuronal activity remains largely …
and provide flexor–extensor and left–right coordination of neuronal activity remains largely …
Computational modeling of spinal circuits controlling limb coordination and gaits in quadrupeds
Interactions between cervical and lumbar spinal circuits are mediated by long propriospinal
neurons (LPNs). Ablation of descending LPNs in mice disturbs left-right coordination at high …
neurons (LPNs). Ablation of descending LPNs in mice disturbs left-right coordination at high …
A neural basis for motor primitives in the spinal cord
CB Hart, SF Giszter - Journal of Neuroscience, 2010 - Soc Neuroscience
Motor primitives and modularity may be important in biological movement control. However,
their neural basis is not understood. To investigate this, we recorded 302 neurons, making …
their neural basis is not understood. To investigate this, we recorded 302 neurons, making …
Spinal interneurons as gatekeepers to neuroplasticity after injury or disease
LV Zholudeva, VE Abraira… - Journal of …, 2021 - Soc Neuroscience
Spinal interneurons are important facilitators and modulators of motor, sensory, and
autonomic functions in the intact CNS. This heterogeneous population of neurons is now …
autonomic functions in the intact CNS. This heterogeneous population of neurons is now …
Epidural spinal cord stimulation as an intervention for motor recovery after motor complete spinal cord injury
JT Hachmann, A Yousak, JJ Wallner… - Journal of …, 2021 - journals.physiology.org
Spinal cord injury (SCI) commonly results in permanent loss of motor, sensory, and
autonomic function. Recent clinical studies have shown that epidural spinal cord stimulation …
autonomic function. Recent clinical studies have shown that epidural spinal cord stimulation …
Central control of interlimb coordination and speed‐dependent gait expression in quadrupeds
Key points Quadrupeds express different gaits depending on speed of locomotion. Central
pattern generators (one per limb) within the spinal cord generate locomotor oscillations and …
pattern generators (one per limb) within the spinal cord generate locomotor oscillations and …
Impulses of activation but not motor modules are preserved in the locomotion of subacute stroke patients
It has been hypothesized that the coordinated activation of muscles is controlled by the
central nervous system by means of a small alphabet of control signals (also referred to as …
central nervous system by means of a small alphabet of control signals (also referred to as …
Neuronal activity in the isolated mouse spinal cord during spontaneous deletions in fictive locomotion: insights into locomotor central pattern generator organization
Key points• The organization of the spinal circuitry responsible for the generation of
locomotor rhythm and control of locomotion in mammals is largely unknown, though several …
locomotor rhythm and control of locomotion in mammals is largely unknown, though several …
State-dependent rhythmogenesis and frequency control in a half-center locomotor CPG
The spinal locomotor central pattern generator (CPG) generates rhythmic activity with
alternating flexion and extension phases. This rhythmic pattern is likely to result from …
alternating flexion and extension phases. This rhythmic pattern is likely to result from …