We review the mechanisms responsible for amino acid homeostasis in Saccharomyces
cerevisiae and other fungi. Amino acid homeostasis is essential for cell growth and survival …

Cells survey their environment and need to balance growth and anabolism with stress
programmes and catabolism towards maximum cellular bioenergetics economy and …

After endocytosis, membrane proteins can recycle to the cell membrane or be degraded in
lysosomes. Cargo ubiquitylation favors their lysosomal targeting and can be regulated by …

Mammalian target of rapamycin complex 1 (TORC1) is controlled by the GATOR complex
composed of the GATOR1 subcomplex and its inhibitor, the GATOR2 subcomplex, sensitive …

In the fission yeast Schizosaccharomyces pombe, the duration of survival in the stationary
phase, termed the chronological lifespan (CLS), is affected by various environmental factors …

TOR complex 1 (TORC1) is an evolutionarily conserved protein kinase complex that
promotes cellular macromolecular synthesis and suppresses autophagy. Amino-acid …

Extracellular cues regulate cell fate, and this is mainly achieved through the engagement of
specific transcriptional programs. The TORC1 and TORC2 complexes mediate the …

The target of rapamycin (TOR) kinase regulates cell growth and division. Rapamycin only
inhibits a subset of TOR activities. Here we show that in contrast to the mild impact of …

Leucine (Leu) is a branched-chain, essential amino acid in animals, including humans.
Fungi, including the fission yeast Schizosaccharomyces pombe, can biosynthesize Leu, but …

ABSTRACT The Tsc1–Tsc2 complex homologous to human tuberous sclerosis complex
proteins governs amino acid uptake by regulating the expression and intracellular …