Local BMP2 hydrogel therapy for robust bone regeneration in a porcine model of Legg-Calvé-Perthes disease

C Ma, MS Park, F Alves do Monte, V Gokani… - NPJ Regenerative …, 2023 - nature.com
Abstract Legg-Calvé-Perthes disease is juvenile idiopathic osteonecrosis of the femoral
head (ONFH) that has no effective clinical treatment. Previously, local injection of bone …

Anti‐Interleukin‐6 therapy decreases hip synovitis and bone resorption and increases bone formation following ischemic osteonecrosis of the femoral head

Y Ren, Z Deng, V Gokani, M Kutschke… - Journal of Bone and …, 2020 - academic.oup.com
ABSTRACT Legg‐Calvé‐Perthes disease (LCPD) is a juvenile form of ischemic femoral
head osteonecrosis, which produces chronic hip synovitis, permanent femoral head …

Does transepiphyseal drilling and closure of the greater trochanter in early Legg-Calve-Perthes disease improve natural history?

M Eidelman, P Kotlarsky - Musculoskeletal surgery, 2023 - Springer
Purpose There is no consensus regarding treatment of Legg-Calve-Perthes disease
(LCPD). The most common sequel of the disease is coxa breva and overgrowth of the …

Minimally invasive necrotic bone washing improves bone healing after femoral head ischemic osteonecrosis: an experimental investigation in immature pigs

HKW Kim, MS Park, FA Do Monte, V Gokani… - JBJS, 2021 - journals.lww.com
Background: Ischemic osteonecrosis of the femoral head produces necrotic cell debris and
inflammatory molecules in the marrow space, which elicit a chronic inflammatory repair …

Quantitative T2 and T1ρ mapping are sensitive to ischemic injury to the epiphyseal cartilage in an in vivo piglet model of Legg-Calvé-Perthes disease

AR Armstrong, S Bhave, EO Buko, KL Chase… - Osteoarthritis and …, 2022 - Elsevier
Objective To determine if the quantitative MRI techniques T2 and T1ρ mapping are sensitive
to ischemic injury to epiphyseal cartilage in vivo in a piglet model of Legg-Calvé-Perthes …

Analysis of trabecular microstructure and vascular distribution of capital femoral epiphysis relevant to legg–calve–perthes disease

WZ Morris, RW Liu, E Chen… - Journal of Orthopaedic …, 2019 - Wiley Online Library
ABSTRACT Legg–Calve–Perthes disease is characterized by the capital femoral epiphyseal
collapse, which occurs more reliably in the anterior quadrant than the more weight‐bearing …

[HTML][HTML] Development of a novel minimally invasive technique to washout necrotic bone marrow content from epiphyseal bone: A preliminary cadaveric bone study

FA do Monte, MS Park, V Gokani, M Singhal… - … & Traumatology: Surgery …, 2020 - Elsevier
Abstract Introduction Legg-Calvé-Perthes disease is a juvenile ischemic osteonecrosis
which produces extensive necrotic cell debris and release of damage associated molecular …

[HTML][HTML] Local Administration of Bone Morphogenetic Protein-2 Using a Hydrogel Carrier for Robust Bone Regeneration in a Large Animal Model of Legg-Calvé …

H Kim, C Ma, M Park, F Monte, V Gokani… - Research …, 2023 - ncbi.nlm.nih.gov
Abstract Legg-Calvé-Perthes disease is juvenile idiopathic osteonecrosis of the femoral
head (ONFH) that has no effective clinical resolutions. Previously, local injection of bone …

What is New in Pediatric Orthopaedic: Basic Science

B Lynch, D Botros, M Halanski… - Journal of Pediatric …, 2023 - journals.lww.com
Background: An understanding of musculoskeletal basic science underpins most
advancements in the field of orthopaedic surgery. Knowledge of biomechanics, genetics …

Prognostic value of bone resorption pattern in the anterior portion of the femoral head in Legg–Calvé–Perthes disease

K Mishima, Y Kamiya, M Matsushita… - Journal of Children's …, 2023 - journals.sagepub.com
Purpose: To examine whether differences in bone resorption patterns in the anterior portion
of the femoral head correlate with the prognosis of Legg–Calvé–Perthes disease. Methods …