Small molecule tractable PARP inhibitors: Scaffold construction approaches, mechanistic insights and structure activity relationship

A Thakur, M Rana, J Mathew, S Nepali, CH Pan… - Bioorganic …, 2023 - Elsevier
Diverse drug design strategies viz. molecular hybridization, substituent installation, scaffold
hopping, isosteric replacement, high-throughput screening, induction and separation of …

Haemostatic Gene Expression in Cancer-Related Immunothrombosis: Contribution for Venous Thromboembolism and Ovarian Tumour Behaviour

V Tavares, J Savva-Bordalo, M Rei, J Liz-Pimenta… - Cancers, 2024 - mdpi.com
Simple Summary The exploration of prognostic biomarkers in ovarian cancer (OC) persists
due to the daunting challenge of therapy resistance and poor patient outcomes …

No evidence for a genetic causal effect of breast cancer on venous thromboembolism: a Mendelian randomization study

Q Qin, Y Pan, L Wang - Journal of Thrombosis and Thrombolysis, 2024 - Springer
Active cancer is known to contribute to venous thromboembolism (VTE), but the cause-and-
effect association of breast cancer on VTE is not yet clear. In order to investigate the possible …

The role of thrombomodulin in modulating ITGB3 expression and its implications for triple‐negative breast cancer progression

YJ Chang, GMSH Prince, PL Wei… - Cell Biology …, 2024 - Wiley Online Library
Triple‐negative breast cancer (TNBC) is the most aggressive subtype of breast cancer (BC)
compared to other BC subtypes in clinical settings. Currently, there are no effective …

Chemopreventive approach of Indian spice “Curcumin” in the treatment of breast cancer

A Deb, M Mishra, B Kumar… - Trends in …, 2024 - eprints.tiu.edu.iq
One of the primary concerns for women in good health is breast cancer. The most typical
hazardous growth is this one. It spreads easily, and the clinical conditions are terrible …

Exploring the Role of Curcumin in Cancer: A Long Road Ahead

P Tiwary, K Oswal, D Kumar - 2023 - Springer
Curcumin is a natural compound that is extracted from the rhizomes of Curcuma longa, also
known as turmeric. Its bright yellow color and hydrophobic nature make it a unique …