Increasing evidence suggests that circulating tumour cells (CTCs) are responsible for
metastatic relapse and this has fuelled interest in their detection and quantification. Although …

Nestin is a class VI intermediate filament protein that was originally described as a neuronal
stem cell marker during central nervous system (CNS) development, and is currently widely …

Background A limitation of positive selection strategies to enrich for circulating tumor cells
(CTCs) is that there might be CTCs with insufficient expression of the surface target marker …

Circulating tumor cells (CTCs) are of recognized importance for diagnosis and prognosis of
cancer patients. With melanoma, most studies do not show any clear relationship between …

Since the identification of self-renewing cells in the hematopoietic system, stem cells have
transformed the study of medicine. Cancer biologists have identified stem-like cells in …

Cancer stem cells (CSCs) play critical roles in cancer initiation, metastasis, recurrence, and
drug resistance. Recent studies have revealed involvement of cancer-associated fibroblasts …

Squamous cells carcinoma (SCC) is the second most frequent of the keratinocyte‐derived
malignancies after basal cell carcinoma and is associated with a significant psychosocial …

Different molecular markers have been identified for melanoma-initiating cells including
CD133 and nestin. Assuming that metastasis requires a dissemination of tumor-initiating …

Melanoma is an aggressive tumor with increasing incidence worldwide. Biomarkers are
valuable tools to minimize the cost and improve efficacy of treatment of this deadly disease …

SOX2 is an embryonic neural crest stem‐cell transcription factor recently shown to be
expressed in human melanoma and to correlate with experimental tumor growth. SOX2 …