Review of bilayer tablet technology

A Abebe, I Akseli, O Sprockel, N Kottala… - International journal of …, 2014 - Elsevier
Therapeutic strategies based on oral delivery of bilayer (and multilayer) tablets are gaining
more acceptance among brand and generic products due to a confluence of factors …

Bilayer tablets: A developing novel drug delivery system

M Akhtar, M Jamshaid, M Zaman, AZ Mirza - Journal of Drug Delivery …, 2020 - Elsevier
Bilayer tablets are the medicines which consist of two same or different drugs combined in a
single dose for effective treatment of the disease. The aim of this review is to reveal the …

[HTML][HTML] Implementation of quality by design (QbD) for development of bilayer tablets

J Simão, SA Chaudhary, AJ Ribeiro - European Journal of Pharmaceutical …, 2023 - Elsevier
Bilayer tablets offer various drug release profiles for individual drugs incorporated in each
layer of a bilayer tablet, which is rarely achievable by conventional tablets. These tablets …

Gastro-floating bilayer tablets for the sustained release of metformin and immediate release of pioglitazone: Preparation and in vitro/in vivo evaluation

W He, Y Li, R Zhang, Z Wu, L Yin - International journal of pharmaceutics, 2014 - Elsevier
Owing to the complementary mechanisms of action of metformin hydrochloride (MH) and
pioglitazone hydrochloride (PG), combination therapy for type 2 diabetes mellitus using the …

Mechanisms of crack formation in die compacted powders during unloading and ejection: An experimental and modeling comparison between standard straight and …

S Garner, E Ruiz, J Strong, A Zavaliangos - Powder technology, 2014 - Elsevier
In an effort to identify the origin and the evolution of damage during the compaction/ejection
cycle of powder compacts, an experimental study that compares compacts in straight and …

Role of the elasticity of pharmaceutical materials on the interfacial mechanical strength of bilayer tablets

V Busignies, V Mazel, H Diarra, P Tchoreloff - International journal of …, 2013 - Elsevier
The effect of the elasticity of various pharmaceutical materials on the interfacial adhesion in
bilayer tablets was investigated. The elastic properties of five pharmaceutical products were …

Tensile and shear methods for measuring strength of bilayer tablets

SY Chang, J Li, CC Sun - International journal of pharmaceutics, 2017 - Elsevier
Both shear and tensile measurement methods have been used to quantify interfacial
bonding strength of bilayer tablets. The shear method is more convenient to perform, but …

Comparison of breaking tests for the characterization of the interfacial strength of bilayer tablets

L Castrati, V Mazel, V Busignies, H Diarra… - International Journal of …, 2016 - Elsevier
The bilayer tableting technology is gaining more acceptance in the drug industry, due to its
ability to improve the drug delivery strategies. It is currently assessed by the European …

Interfacial strength of bilayer pharmaceutical tablets

J Zhang, CY Wu, D Storey, G Byrne - Powder technology, 2018 - Elsevier
The oral drug delivery system using bilayer (or multilayer) tablets has been more commonly
used in therapeutic strategies. However, one of the most common problems associated with …

Development of a new test for the easy characterization of the adhesion at the interface of bilayer tablets: Proof-of-concept study by experimental design

V Busignies, V Mazel, H Diarra, P Tchoreloff - International journal of …, 2014 - Elsevier
Although, adhesion at the interface of bilayer tablets is critical for their design it is difficult to
characterize this adhesion between layers. In view of this, a new test with an easy …