Accurate and complete replication of the genome in every cell division is a prerequisite of
genomic stability. Thus, both prokaryotic and eukaryotic replication forks are extremely …

Abstract Structure-specific endonucleases (SSEs) have key roles in DNA replication,
recombination and repair, and emerging roles in transcription. These enzymes have …

The inheritance of parental histones across the replication fork is thought to mediate
epigenetic memory. Here, we reveal that fission yeast Mrc1 (CLASPIN in humans) binds H3 …

CRYPTOCHROME (CRY) is the primary circadian photoreceptor in Drosophila. We show
that CRY binding to TIMELESS (TIM) is light-dependent in flies and irreversibly commits TIM …

The Timeless protein is essential for circadian rhythm in Drosophila. The Timeless
orthologue in mice is essential for viability and appears to be required for the maintenance …

Faithful duplication of the genome is a challenge because DNA is susceptible to damage by
a number of intrinsic and extrinsic genotoxins, such as free radicals and UV light. Cells …

UV-induced DNA damage stalls DNA replication forks and activates the intra-S checkpoint to
inhibit replicon initiation. In response to stalled replication forks, ATR phosphorylates and …

During S-phase, the genome is extremely vulnerable and the progression of replication forks
is often threatened by exogenous and endogenous challenges. When replication fork …

Mrc1 (mediator of replication checkpoint), Tof1 (topoisomerase I interacting factor), and
Csm3 (chromosome segregation in meiosis) are checkpoint-mediator proteins that function …

Swi1 is required for programmed pausing of replication forks near the mat1 locus in the
fission yeast Schizosaccharomyces pombe. This fork pausing is required to initiate a …