Fragile X syndrome (FXS) results from a genetic mutation in a single gene yet produces a
phenotypically complex disorder with a range of neurological and psychiatric problems …

Fragile X syndrome (FXS), the most-frequently inherited form of intellectual disability and the
most-prevalent single-gene cause of autism, results from a lack of fragile X mental …

Technologies that can safely edit genes in the brains of adult animals may revolutionize the
treatment of neurological diseases and the understanding of brain function. Here, we …

Loss of FMRP causes fragile X syndrome (FXS), but the physiological functions of FMRP
remain highly debatable. Here we show that FMRP regulates neurotransmitter release in …

De novo protein synthesis is necessary for long-lasting modifications in synaptic strength
and dendritic spine dynamics that underlie cognition. Fragile X syndrome (FXS) …

Fragile X syndrome (FXS) is the most common inherited form of intellectual disability and the
leading monogenic cause of autism. The condition stems from loss of fragile X mental …

Fragile X is the most common known inherited cause of intellectual disability and autism,
and it typically results from transcriptional silencing of FMR1 and loss of the encoded …

Loss of the translational repressor FMRP causes Fragile X syndrome. In healthy neurons,
FMRP modulates the local translation of numerous synaptic proteins. Synthesis of these …

Abstract Since Hodgkin and Huxley discovered the potassium current that underlies the
falling phase of action potentials in the squid giant axon, the diversity of voltage‐gated …

N-Methyl-d-Aspartate Receptors (NMDARs) are ionotropic glutamate-gated receptors.
NMDARs are tetramers composed by several homologous subunits of GluN1-, GluN2-, or …