The animal trypanosomiases and their chemotherapy: a review

F Giordani, LJ Morrison, TG Rowan, HP De Koning… - Parasitology, 2016 - cambridge.org
Pathogenic animal trypanosomes affecting livestock have represented a major constraint to
agricultural development in Africa for centuries, and their negative economic impact is …

An update on African trypanocide pharmaceutics and resistance

KI Kasozi, ET MacLeod, I Ntulume… - Frontiers in Veterinary …, 2022 - frontiersin.org
African trypanosomiasis is associated with Trypanosoma evansi, T. vivax, T. congolense,
and T. brucei pathogens in African animal trypanosomiasis (AAT) while T. b gambiense and …

Drugs and drug resistance in African trypanosomiasis

V Delespaux, HP de Koning - Drug resistance updates, 2007 - Elsevier
Despite the many decades of use of most of the current trypanocides, we know little of their
mode of action. This may in part be because most of these will act on multiple targets once …

High prevalence of drug resistance in animal trypanosomes without a history of drug exposure

S Chitanga, T Marcotty, B Namangala… - PLoS neglected …, 2011 - journals.plos.org
Background Trypanosomosis caused by Trypanosoma congolense is a major constraint to
animal health in sub-Saharan Africa. Unfortunately, the treatment of the disease is impaired …

Molecular tools for the rapid detection of drug resistance in animal trypanosomes

V Delespaux, D Geysen, P Van den Bossche… - Trends in …, 2008 - cell.com
There are currently 17 African countries in which animal trypanocidal drug resistance has
been reported. Large-scale surveys were carried out in only ten of them. The lack of …

African animal trypanosomiasis: A systematic review on prevalence, risk factors and drug resistance in sub-Saharan Africa

I Okello, E Mafie, G Eastwood… - Journal of medical …, 2022 - academic.oup.com
African animal trypanosomiasis (AAT) a parasitic disease of livestock in sub-Saharan Africa
causing tremendous loses. Sub-Saharan continental estimation of mean prevalence in both …

[HTML][HTML] Pharma to farmer: field challenges of optimizing trypanocide use in African animal trypanosomiasis

S Richards, LJ Morrison, SJ Torr, MP Barrett… - Trends in …, 2021 - cell.com
Trypanocides are a key control component of African animal trypanosomiasis (AAT) in tsetse-
infested areas of sub-Saharan Africa. While farmers are dependent upon trypanocides …

[HTML][HTML] The COMBAT project: controlling and progressively minimizing the burden of vector-borne animal trypanosomosis in Africa

A Boulangé, V Lejon, D Berthier, S Thévenon… - Open Research …, 2022 - ncbi.nlm.nih.gov
Vector-borne diseases affecting livestock have serious impacts in Africa. Trypanosomosis is
caused by parasites transmitted by tsetse flies and other blood-sucking Diptera. The animal …

Cloning and Characterization of Trypanosoma congolense and T. vivax Nucleoside Transporters Reveal the Potential of P1-Type Carriers for the Discovery of Broad …

MA Ungogo, MM Aldfer, MJ Natto, H Zhuang… - International journal of …, 2023 - mdpi.com
African Animal Trypanosomiasis (AAT), caused predominantly by Trypanosoma brucei
brucei, T. vivax and T. congolense, is a fatal livestock disease throughout Sub-Saharan …

[HTML][HTML] Functional expression of TcoAT1 reveals it to be a P1-type nucleoside transporter with no capacity for diminazene uptake

JC Munday, KER López, AA Eze, V Delespaux… - International Journal for …, 2013 - Elsevier
It has long been established that the Trypanosoma brucei TbAT1/P2 aminopurine
transporter is involved in the uptake of diamidine and arsenical drugs including …